Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol transporter | 0.0441 | 1 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0112 | 0.1659 | 0.0795 |
Echinococcus multilocularis | solute carrier family 5 | 0.0441 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0091 | 0.0969 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.0939 | 0.5661 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0091 | 0.0548 |
Schistosoma mansoni | inositol transporter | 0.0441 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0112 | 0.1659 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.0939 | 0.5661 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0112 | 0.1659 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1659 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0112 | 0.1659 | 0.0795 |
Schistosoma mansoni | high-affinity choline transporter | 0.0112 | 0.1659 | 0.0795 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0112 | 0.1659 | 0.0795 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0112 | 0.1659 | 0.0795 |
Onchocerca volvulus | 0.0112 | 0.1659 | 1 | |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0441 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0939 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0939 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0441 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0091 | 0.0969 |
Echinococcus granulosus | solute carrier family 5 | 0.0441 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1659 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0112 | 0.1659 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0441 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0441 | 1 | 1 |
Brugia malayi | GH02984p | 0.0112 | 0.1659 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.