Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3353 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.3353 | 0.3353 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.3353 | 0.6505 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.5155 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.4759 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5155 | 0.7321 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3353 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0925 | 0.1794 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.3353 | 0.7046 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0925 | 0.0925 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.1721 | 0.1721 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.3353 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.5155 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.3353 | 0.3353 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3353 | 0.5 |
Brugia malayi | RNA binding protein | 0.0064 | 0.5155 | 0.5155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5155 | 0.7321 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.3353 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.3353 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.3353 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.3353 | 0.3353 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.4759 | 0.4759 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.3353 | 0.3353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5155 | 0.7321 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.3353 | 0.3353 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.3353 | 0.6505 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.3353 | 0.3353 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.3353 | 0.3353 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.7041 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5155 | 0.7321 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.3353 | 0.4762 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0925 | 0.0925 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0925 | 0.1313 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.3353 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.3353 | 0.4762 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.5155 | 0.5155 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.3353 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.5155 | 0.5155 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.3353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.327 | 0.6344 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.3353 | 0.3353 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0925 | 0.0925 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.3353 | 0.3353 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0925 | 0.1313 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.3353 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.468 | 0.9079 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.5155 | 0.5155 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.4759 | 0.4759 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.5155 | 0.5155 |
Brugia malayi | cell division control protein 2 homolog | 0.0052 | 0.3353 | 0.3353 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.3353 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.3353 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.5155 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.3353 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.6758 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.3353 | 0.6505 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.1721 | 0.1721 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.4759 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.6758 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.314 | 0.6092 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.4759 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.3353 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.5155 | 0.7321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 391 nM | Inhibition of CDK5/p25 by scintillation proximity assay | ChEMBL. | 19700321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.