Detailed information for compound 1070939

Basic information

Technical information
  • TDR Targets ID: 1070939
  • Name: 2-[4-[(2,3-difluorophenyl)methyl]-1-(2-phenyl ethyl)piperazin-2-yl]ethanol
  • MW: 360.441 | Formula: C21H26F2N2O
  • H donors: 1 H acceptors: 1 LogP: 3.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1CCc1ccccc1)Cc1cccc(c1F)F
  • InChi: 1S/C21H26F2N2O/c22-20-8-4-7-18(21(20)23)15-24-12-13-25(19(16-24)10-14-26)11-9-17-5-2-1-3-6-17/h1-8,19,26H,9-16H2
  • InChiKey: UYDGVBPSHMIHTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[(2,3-difluorophenyl)methyl]-1-(2-phenylethyl)-2-piperazinyl]ethanol
  • 2-[4-(2,3-difluorobenzyl)-1-(2-phenylethyl)piperazin-2-yl]ethanol
  • MLS001000227
  • SMR000495148

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.358 0.358
Echinococcus granulosus Endonuclease G 0.004 0.1368 0.3821
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0501 0.0501
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Leishmania major hypothetical protein, conserved 0.003 0.06 0.4387
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0501 0.14
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0501 0.0501
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0501 0.14
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0501 0.14
Schistosoma mansoni biogenic amine receptor 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Brugia malayi Serotonin receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0501 0.14
Brugia malayi GnHR receptor homolog 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.06 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0501 0.14
Trypanosoma brucei endonuclease G, putative 0.004 0.1368 1
Brugia malayi AKH receptor 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.004 0.1368 1
Brugia malayi G-protein coupled receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi endonuclease G, mitochondrial precursor 0.004 0.1368 0.1368
Schistosoma mansoni biogenic amine receptor 0.0029 0.0501 0.0501
Echinococcus granulosus sex peptide receptor 0.0029 0.0501 0.14
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus somatostatin receptor 0.0029 0.0501 0.14
Echinococcus granulosus g protein coupled receptor 0.0029 0.0501 0.14
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0501 0.14
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0501 0.14
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0501 0.0501
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0501 0.14
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus orexin receptor type 2 0.0029 0.0501 0.14
Trypanosoma cruzi endonuclease G, putative 0.004 0.1368 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0501 0.0501
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0501 0.14
Brugia malayi putative neuropeptide receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0501 0.14
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0501 0.14
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0066 0.358 0.358
Schistosoma mansoni opsin-like receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni opsin-like receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis somatostatin receptor 0.0029 0.0501 0.14
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0501 0.14
Schistosoma mansoni opsin-like receptor 0.0029 0.0501 0.0501
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0501 0.14
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0501 0.0501
Echinococcus granulosus hypothetical protein 0.0029 0.0501 0.14
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0501 0.0501
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0501 0.0501
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0066 0.358 0.358
Echinococcus multilocularis Endonuclease G 0.004 0.1368 0.3821
Trypanosoma cruzi endonuclease G, putative 0.004 0.1368 1
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0501 0.14
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0066 0.358 0.358
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0501 0.0501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0501 0.14
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0501 0.0501
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0501 0.14
Schistosoma mansoni amine GPCR 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.003 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Brugia malayi Dopamine receptor protein 1 0.0029 0.0501 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0066 0.358 0.358
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0501 0.14
Brugia malayi Dopamine receptor 0.0029 0.0501 0.0501
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0501 0.14
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0501 0.14
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0501 0.14
Schistosoma mansoni hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0501 0.14
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0501 0.0501
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0501 0.0501
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.06 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0501 0.0501
Schistosoma mansoni hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Schistosoma mansoni neuropeptide receptor 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0501 0.14
Schistosoma mansoni endonuclease related 0.004 0.1368 0.1368
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0501 0.14
Brugia malayi Dopamine receptor protein 2 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0501 0.14
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0501 0.14
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0501 0.0501
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0501 0.0501
Schistosoma mansoni amine GPCR 0.0029 0.0501 0.0501
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0501 0.14
Schistosoma mansoni amine GPCR 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Brugia malayi G protein-coupled receptor 0.0029 0.0501 0.0501
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0501 0.14
Schistosoma mansoni amine GPCR 0.0029 0.0501 0.0501
Schistosoma mansoni neuropeptide receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0501 0.14
Brugia malayi Melatonin receptor type 1A 0.0029 0.0501 0.0501
Echinococcus granulosus g protein coupled receptor 0.0029 0.0501 0.14
Brugia malayi Serotonin receptor 0.0029 0.0501 0.0501
Onchocerca volvulus 0.0066 0.358 0.3241
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0501 0.0501
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0501 0.14
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0501 0.14
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0501 0.14
Echinococcus granulosus ectonucleotide 0.0056 0.2709 0.7566
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0501 0.14
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0501 0.14
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0501 0.0501
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.004 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0501 0.0501
Echinococcus granulosus fmrfamide receptor 0.0029 0.0501 0.14
Brugia malayi RE15519p 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0066 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi sulfakinin receptor protein 0.0029 0.0501 0.0501
Echinococcus multilocularis sex peptide receptor 0.0029 0.0501 0.14
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0501 0.0501
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0501 0.0501
Brugia malayi neuropeptide F receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0501 0.0501
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0501 0.14
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Brugia malayi G-protein coupled receptor 0.0029 0.0501 0.0501
Trypanosoma brucei endonuclease G, putative 0.004 0.1368 1
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0501 0.14
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0501 0.14
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.004 0.1368 1
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0501 0.14
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis serotonin receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0501 0.14
Schistosoma mansoni amine GPCR 0.0029 0.0501 0.0501
Schistosoma mansoni neuropeptide receptor 0.0029 0.0501 0.0501
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0501 0.0501
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0501 0.0501
Trypanosoma brucei endonuclease G, putative 0.004 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.003 0.06 0.06
Echinococcus granulosus g protein coupled receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0066 0.358 0.358
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0501 0.14
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0501 0.0501
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.004 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0501 0.14
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.06 0.4387
Echinococcus multilocularis ectonucleotide 0.0056 0.2709 0.7566
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0066 0.358 0.358
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0501 0.14
Brugia malayi neuropeptide F receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0501 0.14
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni histamine h1 receptor 0.0029 0.0501 0.0501
Echinococcus granulosus serotonin receptor 0.0029 0.0501 0.14
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0056 0.2709 0.7566
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0056 0.2709 0.7566
Echinococcus granulosus neuropeptide receptor 0.0029 0.0501 0.14
Schistosoma mansoni adenoreceptor 0.0029 0.0501 0.0501
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0501 0.14
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.06 0.4387
Loa Loa (eye worm) hypothetical protein 0.0056 0.2709 0.2709
Brugia malayi larval opioid receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis serotonin receptor 0.0029 0.0501 0.14
Schistosoma mansoni hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni biogenic amine receptor 0.0029 0.0501 0.0501
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0066 0.358 1
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0501 0.0501
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0501 0.0501
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0501 0.14
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0501 0.14
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0501 0.14
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0501 0.0501
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0501 0.14
Schistosoma mansoni myosin xvIII 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0501 0.0501
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Schistosoma mansoni neuropeptide receptor 0.0029 0.0501 0.0501
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0501 0.0501
Brugia malayi ORL1-like opioid receptor 0.0029 0.0501 0.0501
Echinococcus granulosus allatostatin A receptor 0.0029 0.0501 0.14
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0501 0.14
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Brugia malayi hypothetical protein 0.0029 0.0501 0.0501
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.06 0.4387
Loa Loa (eye worm) hypothetical protein 0.0029 0.0501 0.0501
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.06 0.5
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0501 0.14
Echinococcus granulosus neuropeptide receptor 0.0029 0.0501 0.14
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0501 0.0501
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0501 0.14
Onchocerca volvulus 0.0066 0.358 0.3241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0501 0.14
Leishmania major endonuclease G, putative 0.004 0.1368 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0501 0.14

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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