Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.5073 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Onchocerca volvulus | 0.0096 | 0.5073 | 1 | |
Leishmania major | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.5073 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1762 | 0.1762 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1762 | 0.1762 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2709 | 0.2709 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1421 | 0.2091 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.5073 | 0.5073 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.5073 | 0.5073 |
Schistosoma mansoni | hexokinase | 0.0096 | 0.5073 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 0.5073 | 0.4257 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 0.5073 | 0.4257 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1421 | 0.1421 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.5073 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.5073 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1421 | 0.2091 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1762 | 0.1762 |
Onchocerca volvulus | 0.0096 | 0.5073 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2302 | 0.2302 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.5073 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0456 | 0.0456 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.2302 | 0.2302 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.5073 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0456 | 0.0456 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.5073 | 0.5073 |
Echinococcus granulosus | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Onchocerca volvulus | 0.0096 | 0.5073 | 1 | |
Brugia malayi | hexokinase | 0.0096 | 0.5073 | 0.5073 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.5073 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.5073 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1421 | 0.2091 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1421 | 0.1421 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1762 | 0.1762 |
Echinococcus multilocularis | hexokinase | 0.0096 | 0.5073 | 0.4257 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.5073 | 0.5073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.95 uM | Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19726182 |
EC50 (binding) | = 6.1 uM | Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19726182 |
Emax (binding) | = 0.85 | Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide | ChEMBL. | 19726182 |
Emax (binding) | = 0.87 | Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose relative to 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide | ChEMBL. | 19726182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.