TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 928.087 | Formula: C47H65N11O9
H donors: 8 H acceptors: 9 LogP: 0.81 Rotable bonds: 24
Rule of 5 violations (Lipinski): 3
SMILES: OCC(C(=O)N(C(C(=O)N)C)C)NC(=O)C1Cc2c3N1C(=O)C(CCc3ccc2)NC(=O)C1Cc2ccccc2CN1C(=O)C(NC(=O)C(NC(=O)C)CC1CCCCC1)CCCN=C(N)N
InChi: 1S/C47H65N11O9/c1-26(40(48)61)56(3)44(65)36(25-59)55-43(64)38-23-31-16-9-15-29-18-19-34(46(67)58(38)39(29)31)54-42(63)37-22-30-13-7-8-14-32(30)24-57(37)45(66)33(17-10-20-51-47(49)50)53-41(62)35(52-27(2)60)21-28-11-5-4-6-12-28/h7-9,13-16,26,28,33-38,59H,4-6,10-12,17-25H2,1-3H3,(H2,48,61)(H,52,60)(H,53,62)(H,54,63)(H,55,64)(H4,49,50,51)
InChiKey: UONIKMVNNXTABW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	protein tyrosine kinase	0.0145	0.5785	0.5785
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/ACK protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	ephrin type A receptor 4 A	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Toxoplasma gondii	STE kinase	0.0145	0.5785	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	ankyrin repeat protein	0.0145	0.5785	0.5785
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Entamoeba histolytica	receptor protein kinase, putative	0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0145	0.5785	0.5
Echinococcus granulosus	insulin receptor	0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0207	1	1
Echinococcus multilocularis	protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/INSR protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Brugia malayi	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	epidermal growth factor receptor	0.0145	0.5785	0.5785
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0207	1	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Leishmania major	protein kinase, putative	0.0145	0.5785	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0145	0.5785	0.5
Schistosoma mansoni	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0145	0.5785	0.5785
Echinococcus multilocularis	epidermal growth factor receptor	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0145	0.5785	0.5785
Echinococcus multilocularis	transfer RNA-Thr	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase HCK	0.0145	0.5785	0.5785
Schistosoma mansoni	serine/threonine RGC	0.0145	0.5785	0.5785
Brugia malayi	SH2 domain containing protein	0.0207	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0207	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0145	0.5785	0.5
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0145	0.5785	0.5
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Trypanosoma brucei	Pseudokinase, putative	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0207	1	1
Onchocerca volvulus		0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0207	1	1
Echinococcus granulosus	activin receptor type	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Echinococcus granulosus	activated cdc42 kinase 1	0.0145	0.5785	0.5785
Echinococcus granulosus	natriuretic peptide receptor 1	0.0145	0.5785	0.5785
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine kinase	0.0207	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0145	0.5785	0.5785
Brugia malayi	hypothetical protein	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0207	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	activin receptor type	0.0145	0.5785	0.5785
Toxoplasma gondii	protein kinase domain-containing protein	0.0145	0.5785	0.5
Onchocerca volvulus		0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosin kinase, putative	0.0145	0.5785	0.5785
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0145	0.5785	0.5785
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosin kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	FL cytokine receptor	0.0145	0.5785	0.5785
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0145	0.5785	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0145	0.5785	0.5785
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK protein kinase	0.0207	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0145	0.5785	0.5785
Brugia malayi	Furin-like cysteine rich region family protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0145	0.5785	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	protein kinase	0.0145	0.5785	0.5785
Giardia lamblia	Kinase, NEK	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0207	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/EPH protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	serine/threonine protein kinase	0.0145	0.5785	0.5785
Giardia lamblia	Kinase, NEK	0.0145	0.5785	0.5
Onchocerca volvulus		0.0207	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Srms	0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0207	1	1
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	insulin receptor	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0207	1	1
Brugia malayi	Protein kinase domain containing protein	0.0207	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Toxoplasma gondii	protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0145	0.5785	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	ephrin receptor 1 precursor	0.0145	0.5785	0.5785
Brugia malayi	Tyrosine-protein kinase PR2	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0145	0.5785	0.5785
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0145	0.5785	0.5
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	Receptor family ligand binding region containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase pr2	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/Met protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/ROR protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0145	0.5785	0.5785
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Entamoeba histolytica	ankyrin repeat protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0207	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0145	0.5785	0.5785
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Plasmodium falciparum	protein kinase, putative	0.0145	0.5785	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	ephrin receptor	0.0145	0.5785	0.5785
Entamoeba histolytica	cysteine surface protein, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0207	1	1
Brugia malayi	Raf kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Brugia malayi	integrin-linked kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine kinase	0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trypanosoma cruzi	protein kinase, putative	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0145	0.5785	0.5785
Echinococcus granulosus	receptor type guanylyl cyclase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0145	0.5785	0.5785
Echinococcus multilocularis	protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Echinococcus granulosus	c src tyrosine kinase	0.0207	1	1
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0145	0.5785	0.5785
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0207	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Plasmodium vivax	protein kinase, putative	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0207	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0145	0.5785	0.5
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Brugia malayi	SRC-1	0.0207	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase shark	0.0207	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	protein tyrosine kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Brugia malayi	SH2 domain containing protein	0.0207	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Plasmodium falciparum	protein kinase, putative	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0207	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0207	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	activated cdc42 kinase 1	0.0145	0.5785	0.5785
Echinococcus multilocularis	c src tyrosine kinase	0.0207	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0207	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0207	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Plasmodium falciparum	tyrosine kinase-like protein	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	epidermal growth factor receptor	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine kinase	0.0207	1	1
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Schistosoma mansoni	ephrin receptor	0.0145	0.5785	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0207	1	1
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Trypanosoma brucei	protein kinase, putative	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/ABL protein kinase	0.0207	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0145	0.5785	0.5785
Echinococcus granulosus	epidermal growth factor receptor	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0207	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosin kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0145	0.5785	0.5785
Trichomonas vaginalis	TK family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0207	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Brugia malayi	Tyrosine-protein kinase abl-1	0.0207	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0207	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Schistosoma mansoni	protein kinase	0.0145	0.5785	0.5785
Brugia malayi	C-terminal src kinase protein 1	0.0145	0.5785	0.5785
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase shark	0.0207	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0145	0.5785	0.5785
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0207	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0145	0.5785	0.5785
Giardia lamblia	Protein 21.1	0.0145	0.5785	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Echinococcus granulosus	activated cdc42 kinase 1	0.0145	0.5785	0.5785
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0207	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0207	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0207	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0145	0.5785	0.5785
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0207	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0145	0.5785	0.5785
Leishmania major	protein kinase, putative	0.0145	0.5785	0.5
Giardia lamblia	Kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0145	0.5785	0.5785
Echinococcus multilocularis	heat shock protein 70	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Onchocerca volvulus		0.0207	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0207	1	1
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	hypothetical protein	0.0145	0.5785	0.5785
Brugia malayi	protein-tyrosine kinase	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0207	1	1
Trichomonas vaginalis	STE family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Plasmodium falciparum	protein kinase, putative	0.0145	0.5785	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK/CSK protein kinase	0.0145	0.5785	0.5785
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0145	0.5785	0.5785
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	TK protein kinase	0.0145	0.5785	0.5785
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	protein kinase atn1, putative	0.0145	0.5785	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.5785	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0145	0.5785	0.5785
Loa Loa (eye worm)	SRC-1	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	CAMK family protein kinase	0.0145	0.5785	0.5
Leishmania major	hypothetical protein, conserved	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0207	1	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0145	0.5785	0.5785
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0207	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Onchocerca volvulus		0.0207	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0145	0.5785	0.5785
Trypanosoma cruzi	protein kinase, putative	0.0145	0.5785	0.5
Brugia malayi	Protein kinase domain containing protein	0.0145	0.5785	0.5785
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0145	0.5785	0.5785
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0145	0.5785	0.5785
Entamoeba histolytica	hypothetical protein	0.0145	0.5785	0.5785
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0145	0.5785	0.5
Schistosoma mansoni	tyrosine kinase	0.0145	0.5785	0.5785
Entamoeba histolytica	tyrosine kinase, putative	0.0145	0.5785	0.5785

Activities

Activity type	Activity value	Assay description	Source	Reference
Degradation (binding)	= 109 %	Percent degraded by the cathepsin B after incubation for 4 hrs was determined by HPLC	ChEMBL.	10841792
Mean relative potency (binding)	= 0.12	Mean relative potency is the ratio of potencies of 'Ac-(Cha)RAMASL-NH2' and compound to inhibit MHC class II DRB1*0101	ChEMBL.	10841792
Mean relative potency (binding)	= 0.27	Mean relative potency is the ratio of potencies of 'Ac-(Cha)RAMASL-NH2' and compound to inhibit MHC class II DRB1*0401	ChEMBL.	10841792
T-cell inhibition (functional)	= 0.2	T-cell inhibitory potency relative to the IC50 of a(Cha)AAAKTAAAAa-NH2 iMHC class II DRB1*0101	ChEMBL.	10841792
T-cell inhibition (functional)	= 0.7	T-cell inhibitory potency relative to the IC50 of a(Cha)AAAKTAAAAa-NH2 in MHC class II DRB1*0401	ChEMBL.	10841792

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 207219

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 108037