TDR Targets

Basic information

Technical information

TDR Targets ID: 1082183
Name: 7-(2-methoxyethoxy)-2-[2-(4-methoxypyridin-2- yl)ethyl]-1H-imidazo[4,5-b]pyridine
MW: 328.366 | Formula: C17H20N4O3
H donors: 1 H acceptors: 3 LogP: 1.76 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCOc1ccnc2c1nc([nH]2)CCc1nccc(c1)OC
InChi: 1S/C17H20N4O3/c1-22-9-10-24-14-6-8-19-17-16(14)20-15(21-17)4-3-12-11-13(23-2)5-7-18-12/h5-8,11H,3-4,9-10H2,1-2H3,(H,19,20,21)
InChiKey: CCICVMYDLWZHRU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

7-(2-methoxyethoxy)-2-[2-(4-methoxy-2-pyridyl)ethyl]-1H-imidazo[4,5-b]pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nitric oxide synthase 2, inducible	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0032	0.0717	0.052
Schistosoma mansoni	hypothetical protein	0.0018	0.0363	0.0363
Brugia malayi	FAD binding domain containing protein	0.0032	0.0717	0.0701
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1311	0.1041
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0396	1	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0156	0.0156
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0032	0.0717	0.052
Schistosoma mansoni	hypothetical protein	0.004	0.0908	0.0908
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0156	0.0156
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0363	0.0346
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0156	0.0139
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0363	0.0346
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0156	0.0139
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0156	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1378	0.1364
Plasmodium falciparum	nitric oxide synthase, putative	0.0032	0.0717	0.052
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0156	0.0156
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0156	0.0139
Brugia malayi	nuclear receptor NHR-88	0.001	0.0156	0.0139
Onchocerca volvulus		0.001	0.0156	0.2229
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0156	0.0139
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0032	0.0015
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0363	0.0346
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0363	0.0346
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0017	0.0017
Chlamydia trachomatis	sulfite reductase	0.002	0.0402	0.5
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0396	1	1
Schistosoma mansoni	nuclear receptor	0.0005	0.0017	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0156	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0156	0.0139
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0032	0.0015
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0363	0.0346
Schistosoma mansoni	hypothetical protein	0.0018	0.0363	0.0363
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0156	0.0156
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0156	0.0156
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1378	0.1364
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1256	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0032	0.0015
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0396	1	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0032	0.0717	0.052
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0156	0.2229
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0396	1	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0032	0.0717	0.0701
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.1256	0.1241
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0032	0.0032
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0396	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0012	0.0208	0.0147
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0032	0.0717	0.0701
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0079	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0156	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0156	0.0139
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0121	0.0105
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.1476	0.1211
Brugia malayi	hypothetical protein	0.0005	0.0032	0.0015
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0032	0.0717	0.052
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0032	0.0717	0.052
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0156	0.0139
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0156	0.0139
Echinococcus granulosus	methionine synthase reductase	0.002	0.0402	0.0385
Brugia malayi	flavodoxin family protein	0.0032	0.0717	0.0701
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0012	0.0208	0.0147
Brugia malayi	hypothetical protein	0.0005	0.0032	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0156	0.0139
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0079	0.0079
Brugia malayi	ecdysteroid receptor	0.001	0.0156	0.0139
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0156	0.0139
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0156	0.2229
Treponema pallidum	flavodoxin	0.0012	0.0208	0.5
Schistosoma mansoni	cpg binding protein	0.0029	0.0641	0.0641
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.1256	0.1241
Schistosoma mansoni	diflavin oxidoreductase	0.0016	0.0302	0.0302
Leishmania major	cytochrome P450 reductase, putative	0.0029	0.0623	0.0424
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0032	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0156	0.0139
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0032	0.0717	0.0701
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.002	0.0402	0.0402
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0396	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0156	0.2229
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.1476	0.1462
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0396	1	1
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0032	0.0717	0.052
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1256	0.1256
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0156	0.0139
Echinococcus multilocularis	cpg binding protein	0.0031	0.0684	0.0668
Giardia lamblia	Nitric oxide synthase, inducible	0.0029	0.0623	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0641	0.0626
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0156	0.0139
Trichomonas vaginalis	sulfite reductase, putative	0.0032	0.0717	0.0659
Brugia malayi	steroid hormone receptor	0.001	0.0156	0.0139
Brugia malayi	FAD binding domain containing protein	0.002	0.0402	0.0385
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0156	0.0139
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0156	0.0156
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0156	0.0139
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0396	1	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.002	0.0402	0.0385
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0396	1	1
Echinococcus multilocularis	methionine synthase reductase	0.002	0.0402	0.0385
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0908	0.0893
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0156	0.0156
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0363	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0032	0.0015
Brugia malayi	nuclear hormone receptor	0.001	0.0156	0.0139
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0029	0.0623	0.0565
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0156	0.0156
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0363	0.0346
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0032	0.0717	0.0701
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0396	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1476	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0363	0.0363
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0032	0.0717	0.052
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0032	0.0717	0.0701
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0017	0.0017
Schistosoma mansoni	coup transcription factor	0.001	0.0156	0.0156
Schistosoma mansoni	hypothetical protein	0.0018	0.0363	0.0363
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0156	0.0139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1378	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0032	0.0015
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0156	0.0139
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0012	0.0208	0.0147
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.1476	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0156	0.0156
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.1256	0.1241
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Echinococcus granulosus	GPCR family 2	0.0018	0.0363	0.0346
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0156	0.0139
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.1256	0.1241
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0124	0.0108
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0032	0.0015
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0124	0.0108
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0156	0.0139
Schistosoma mansoni	cpg binding protein	0.0031	0.0684	0.0684
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0079	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0156	0.0139
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0396	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Brugia malayi	nuclear receptor RXR	0.0005	0.0032	0.0015
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0156	0.0139
Plasmodium vivax	flavodoxin domain containing protein	0.0029	0.0623	0.0424
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0156	0.0139
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0156	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0156	0.0139
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0032	0.0717	0.052
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0156	0.0139
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.1476	0.1476
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0156	0.0139
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0079	0.0062
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0032	0.0015
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0032	0.0032
Trypanosoma cruzi	p450 reductase, putative	0.0032	0.0717	0.052
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0363	0.0346
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0156	0.0139
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1476	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0641	0.0626
Onchocerca volvulus		0.0029	0.0641	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.1476	0.1476
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0156	0.0139
Schistosoma mansoni	cpg binding protein	0.0031	0.0684	0.0684
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.1256	0.1241
Schistosoma mansoni	zinc finger protein	0.0005	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0032	0.0015
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0156	0.0139
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.1476	0.1295
Loa Loa (eye worm)	flavodoxin family protein	0.0012	0.0208	0.0191
Echinococcus granulosus	cpg binding protein	0.0031	0.0684	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0032	0.0015
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0156	0.0139
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1481	0.1481
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0012	0.0208	0.0147
Schistosoma mansoni	nuclear receptor	0.0005	0.0017	0.0017
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.1476	0.1462
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0016	0.0308	0.0308
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0032	0.0717	0.052
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0156	0.0139
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.1256	0.1241
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1378	0.1364
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.004	0.0908	0.0893
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0396	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0124	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0363	0.0346
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0396	1	1
Schistosoma mansoni	cytochrome P450 reductase	0.0032	0.0717	0.0717
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0396	1	1
Giardia lamblia	Hypothetical protein	0.0029	0.0623	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0156	0.0139
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0396	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0017	0.0017
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0156	0.0139
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0079	0.0062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0156	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0156	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0717	0.0701
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0156	0.0139
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0396	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0156	0.0156
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0017	0.0017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0156	0.0156
Leishmania major	p450 reductase, putative	0.0032	0.0717	0.052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0156	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0156	0.0139
Brugia malayi	flavodoxin family protein	0.0012	0.0208	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0156	0.0139
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.1476	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1256	0.1256
Loa Loa (eye worm)	hypothetical protein	0.001	0.0156	0.0139

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.69	Inhibition of human eNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting	ChEMBL.	21684157
IC50 (binding)	= 3.91	Inhibition of human nNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting	ChEMBL.	21684157
IC50 (binding)	= 6.29	Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting	ChEMBL.	21684157

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1800531

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1082183