Detailed information for compound 108512

Basic information

Technical information
  • TDR Targets ID: 108512
  • Name: 1-(6-methoxypyridin-2-yl)-N-[(E)-pyridin-4-yl methylideneamino]pyrazolo[3,4-d]pyrimidin-4-a mine
  • MW: 346.346 | Formula: C17H14N8O
  • H donors: 1 H acceptors: 5 LogP: 2.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(n1)n1ncc2c1ncnc2N/N=C/c1ccncc1
  • InChi: 1S/C17H14N8O/c1-26-15-4-2-3-14(23-15)25-17-13(10-22-25)16(19-11-20-17)24-21-9-12-5-7-18-8-6-12/h2-11H,1H3,(H,19,20,24)/b21-9+
  • InChiKey: DMFMOTPKXUXNGS-ZVBGSRNCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(6-methoxy-2-pyridyl)-N-[(E)-4-pyridylmethyleneamino]pyrazolo[3,4-d]pyrimidin-4-amine
  • 1-(6-methoxy-2-pyridyl)-N-[(E)-4-pyridylmethyleneamino]-4-pyrazolo[3,4-d]pyrimidinamine
  • [1-(6-methoxy-2-pyridyl)pyrazolo[3,4-d]pyrimidin-4-yl]-[(E)-4-pyridylmethyleneamino]amine
  • 1-(6-methoxypyridin-2-yl)-N-(pyridin-4-ylmethylideneamino)pyrazolo[4,5-e]pyrimidin-4-amine
  • 1-(6-methoxy-2-pyridyl)-N-(4-pyridylmethyleneamino)pyrazolo[4,5-e]pyrimidin-4-amine
  • 1-(6-methoxy-2-pyridyl)-N-(4-pyridylmethyleneamino)-4-pyrazolo[4,5-e]pyrimidinamine
  • [1-(6-methoxy-2-pyridyl)pyrazolo[4,5-e]pyrimidin-4-yl]-(4-pyridylmethyleneamino)amine
  • pyrazolopyrimidine derivative 27

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0452 0.1368 0.1368
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0452 0.1368 0.161
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Loa Loa (eye worm) PDE1B protein 0.0452 0.1368 0.1368
Entamoeba histolytica protein kinase, putative 0.0058 0 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 0.161
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2935 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Trypanosoma brucei hypothetical protein, conserved 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1368 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0452 0.1368 0.1368
Leishmania major cAMP-specific phosphodiesterase, putative 0.0452 0.1368 0.161
Plasmodium vivax phosphodiesterase gamma, putative 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0452 0.1368 0.1368
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0452 0.1368 0.1368
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Loa Loa (eye worm) hypothetical protein 0.0452 0.1368 0.1368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0452 0.1368 0.1368
Entamoeba histolytica protein kinase domain containing protein 0.0058 0 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0452 0.1368 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0452 0.1368 0.1622
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2483 0.843 0.843
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0452 0.1368 0.161
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0452 0.1368 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0452 0.1368 0.1368
Plasmodium falciparum phosphodiesterase gamma, putative 0.0452 0.1368 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2483 0.843 0.843
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0452 0.1368 0.1368
Onchocerca volvulus 0.0058 0 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0452 0.1368 0.161
Entamoeba histolytica protein kinase domain containing protein 0.0058 0 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0452 0.1368 0.1622
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0452 0.1368 0.1368
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0452 0.1368 0.1368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0452 0.1368 0.1368
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2483 0.843 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Leishmania major hypothetical protein, conserved 0.0452 0.1368 0.161
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0452 0.1368 0.161
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2483 0.843 0.843
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0452 0.1368 0.1368
Trypanosoma cruzi hypothetical protein, conserved 0.0452 0.1368 0.161
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.0452 0.1368 0.1368
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.2501 0.8494 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0452 0.1368 0.161
Loa Loa (eye worm) hypothetical protein 0.0452 0.1368 0.1368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0452 0.1368 0.1622
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2935 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0452 0.1368 0.1622
Giardia lamblia Hypothetical protein 0.0452 0.1368 0.1368
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0452 0.1368 0.1622
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0452 0.1368 0.161
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0452 0.1368 0.1622
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2935 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Leishmania major hypothetical protein, conserved 0.2501 0.8494 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0452 0.1368 0.161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0452 0.1368 0.1368
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2935 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.2501 0.8494 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2935 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0452 0.1368 0.161
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0452 0.1368 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1368 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0452 0.1368 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0452 0.1368 0.161
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Giardia lamblia hypothetical protein 0.0452 0.1368 0.1368
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0452 0.1368 0.1368
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.2935 1 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0452 0.1368 0.1368
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis conserved hypothetical protein 0.0452 0.1368 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0452 0.1368 0.1368
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0452 0.1368 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0452 0.1368 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0452 0.1368 0.1368
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2935 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0452 0.1368 0.1368
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0452 0.1368 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.4 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992
Log IC50 (binding) = 7.4 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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