Detailed information for compound 108524

Basic information

Technical information
  • TDR Targets ID: 108524
  • Name: N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-(2- methylphenyl)-1,3-oxazol-2-amine
  • MW: 347.367 | Formula: C20H17N3O3
  • H donors: 1 H acceptors: 2 LogP: 4.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1c1cnco1)Nc1ncc(o1)c1ccccc1C
  • InChi: 1S/C20H17N3O3/c1-13-5-3-4-6-15(13)19-11-22-20(26-19)23-14-7-8-16(17(9-14)24-2)18-10-21-12-25-18/h3-12H,1-2H3,(H,22,23)
  • InChiKey: XOSKMGZJNRRPJA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(3-methoxy-4-oxazol-5-yl-phenyl)-5-(o-tolyl)oxazol-2-amine
  • N-[3-methoxy-4-(5-oxazolyl)phenyl]-5-(o-tolyl)-2-oxazolamine
  • (3-methoxy-4-oxazol-5-yl-phenyl)-[5-(o-tolyl)oxazol-2-yl]amine
  • N-(3-methoxy-4-oxazol-5-yl-phenyl)-5-(2-methylphenyl)oxazol-2-amine
  • N-[3-methoxy-4-(5-oxazolyl)phenyl]-5-(2-methylphenyl)-2-oxazolamine
  • (3-methoxy-4-oxazol-5-yl-phenyl)-[5-(2-methylphenyl)oxazol-2-yl]amine
  • (3-Methoxy-4-(1,3-oxazol-5-yl)phenyl)[5-(2-methylphenyl)(1,3-oxazol-2-yl)]amine
  • AIDS-155237
  • AIDS155237

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0173 1 1
Leishmania major guanosine monophosphate reductase 0.0095 0.3643 0.5
Echinococcus granulosus neuropeptide receptor 0.0173 1 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.3643 1
Echinococcus granulosus g protein coupled receptor 0.0173 1 1
Schistosoma mansoni adenoreceptor 0.0173 1 1
Echinococcus granulosus fmrfamide receptor 0.0173 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0173 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0173 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0173 1 1
Echinococcus granulosus g protein coupled receptor 0.0173 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0173 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0173 1 1
Schistosoma mansoni myosin xvIII 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni amine GPCR 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0173 1 1
Echinococcus granulosus g protein coupled receptor 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus allatostatin A receptor 0.0173 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0173 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.3643 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni hypothetical protein 0.0173 1 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.3188 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis allatostatin A receptor 0.0173 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0173 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0173 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0173 1 1
Echinococcus multilocularis fmrfamide receptor 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Brugia malayi G-protein coupled receptor 0.0173 1 1
Brugia malayi Dopamine receptor 0.0173 1 1
Brugia malayi larval opioid receptor 0.0173 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0173 1 1
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0095 0.3643 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0173 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0173 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0173 1 1
Echinococcus multilocularis neuropeptide receptor 0.0173 1 1
Brugia malayi putative neuropeptide receptor 0.0173 1 1
Schistosoma mansoni amine GPCR 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.3188 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis serotonin receptor 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis g protein coupled receptor 0.0173 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Brugia malayi hypothetical protein 0.0173 1 1
Brugia malayi Dopamine receptor protein 2 0.0173 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0173 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0173 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0173 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Echinococcus granulosus hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0173 1 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Trypanosoma brucei GMP reductase 0.0095 0.3643 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi sulfakinin receptor protein 0.0173 1 1
Brugia malayi Serotonin receptor 0.0173 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0173 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0173 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0173 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Trypanosoma cruzi GMP reductase 0.0095 0.3643 0.5
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis neuropeptide receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0173 1 1
Schistosoma mansoni opsin-like receptor 0.0173 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0173 1 1
Schistosoma mansoni hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0173 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0173 1 1
Echinococcus multilocularis g protein coupled receptor 0.0173 1 1
Echinococcus granulosus neuropeptide receptor 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Schistosoma mansoni hypothetical protein 0.0173 1 1
Schistosoma mansoni opsin-like receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0173 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis somatostatin receptor 0.0173 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus granulosus somatostatin receptor 0.0173 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Brugia malayi Dopamine receptor protein 1 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.3643 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0173 1 1
Schistosoma mansoni neuropeptide receptor 0.0173 1 1
Brugia malayi neuropeptide F receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus sex peptide receptor 0.0173 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0173 1 1
Echinococcus granulosus serotonin receptor 0.0173 1 1
Schistosoma mansoni biogenic amine receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Schistosoma mansoni amine GPCR 0.0173 1 1
Schistosoma mansoni neuropeptide receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis g protein coupled receptor 0.0173 1 1
Schistosoma mansoni hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi G-protein coupled receptor 0.0173 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0173 1 1
Brugia malayi Serotonin receptor 0.0173 1 1
Schistosoma mansoni histamine h1 receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0173 1 1
Trypanosoma cruzi GMP reductase 0.0095 0.3643 0.5
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0173 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0173 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni biogenic amine receptor 0.0173 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0173 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis fmrfamide receptor 0.0173 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0173 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0173 1 1
Brugia malayi ORL1-like opioid receptor 0.0173 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0173 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Schistosoma mansoni biogenic amine receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Brugia malayi RE15519p 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0173 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0173 1 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.3643 1
Echinococcus granulosus tm gpcr rhodopsin 0.0173 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus neuropeptide s receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0173 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0173 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0173 1 1
Brugia malayi Melatonin receptor type 1A 0.0173 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0173 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Brugia malayi AKH receptor 0.0173 1 1
Brugia malayi G protein-coupled receptor 0.0173 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0173 1 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.3643 0.5
Schistosoma mansoni opsin-like receptor 0.0173 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0173 1 1
Echinococcus granulosus orexin receptor type 2 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Schistosoma mansoni neuropeptide receptor 0.0173 1 1
Brugia malayi follicle stimulating hormone receptor 0.0173 1 1
Brugia malayi hypothetical protein 0.0173 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0173 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.3643 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0173 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0173 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0173 1 1
Brugia malayi GnHR receptor homolog 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0173 1 1
Brugia malayi neuropeptide F receptor 0.0173 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0173 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0173 1 1
Toxoplasma gondii IMP dehydrogenas 0.0095 0.3643 0.5
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.3643 0.5
Brugia malayi hypothetical protein 0.0173 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0173 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis orexin receptor type 2 0.0173 1 1
Echinococcus multilocularis serotonin receptor 0.0173 1 1
Echinococcus granulosus g-protein coupled receptor 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Onchocerca volvulus 0.0173 1 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0173 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0173 1 1
Echinococcus multilocularis sex peptide receptor 0.0173 1 1
Schistosoma mansoni amine GPCR 0.0173 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0173 1 1
Schistosoma mansoni neuropeptide receptor 0.0173 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0173 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0173 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0173 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0173 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0173 1 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.3643 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0173 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0173 1 0.5
Schistosoma mansoni amine GPCR 0.0173 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 25 nM Inhibition of human inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12014950
IC50 (binding) = 25 nM Inhibition of human inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12014950
IC50 (functional) > 10 uM In vitro secondary T-cell (CEM) proliferation assay ChEMBL. 12014950
IC50 (functional) > 10 uM In vitro secondary T-cell (CEM) proliferation assay ChEMBL. 12014950

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12014950

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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