Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metacaspase, putative | 0.0122 | 0.0268 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0675 | 0.1657 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0122 | 0.0268 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0675 | 0.1657 | 0.1657 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0407 | 0.0984 | 0.0856 |
Echinococcus multilocularis | neuroligin | 0.0675 | 0.1657 | 0.1657 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3995 | 1 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0122 | 0.0268 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0675 | 0.1657 | 0.1538 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0285 | 0.0677 | 0.0677 |
Echinococcus granulosus | caspase | 0.0122 | 0.0268 | 0.0268 |
Onchocerca volvulus | 0.0675 | 0.1657 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3995 | 1 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0122 | 0.0268 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0122 | 0.0268 | 0.013 |
Plasmodium falciparum | metacaspase-like protein | 0.0122 | 0.0268 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0122 | 0.0268 | 0.5 |
Onchocerca volvulus | 0.0675 | 0.1657 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.3995 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3995 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3995 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0285 | 0.0677 | 0.0544 |
Loa Loa (eye worm) | carboxylesterase | 0.0675 | 0.1657 | 0.1538 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0675 | 0.1657 | 0.1657 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0122 | 0.0268 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.011 | 0.0236 | 0.8432 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0122 | 0.0268 | 0.0268 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.011 | 0.0236 | 0.0097 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0122 | 0.0268 | 0.013 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.011 | 0.0236 | 0.8432 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0675 | 0.1657 | 0.1538 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0675 | 0.1657 | 0.1657 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0675 | 0.1657 | 0.1657 |
Brugia malayi | Carboxylesterase family protein | 0.0675 | 0.1657 | 0.1538 |
Echinococcus granulosus | caspase 2 | 0.0407 | 0.0984 | 0.0984 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0675 | 0.1657 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0268 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.011 | 0.0236 | 0.8432 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Echinococcus granulosus | carboxylesterase 5A | 0.3995 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0107 | 0.023 | 0.8096 |
Echinococcus multilocularis | acetylcholinesterase | 0.3995 | 1 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0285 | 0.0677 | 0.0677 |
Echinococcus granulosus | serotonin transporter | 0.0072 | 0.014 | 0.014 |
Echinococcus multilocularis | caspase 2 | 0.0407 | 0.0984 | 0.0984 |
Echinococcus granulosus | acetylcholinesterase | 0.3995 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.0984 | 0.0856 |
Trypanosoma brucei | metacaspase | 0.0122 | 0.0268 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0122 | 0.0268 | 0.013 |
Echinococcus multilocularis | caspase 8 | 0.0122 | 0.0268 | 0.0268 |
Schistosoma mansoni | acetylcholinesterase | 0.0675 | 0.1657 | 0.1538 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0122 | 0.0268 | 0.0268 |
Brugia malayi | Carboxylesterase family protein | 0.0675 | 0.1657 | 0.1538 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0122 | 0.0268 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0675 | 0.1657 | 1 |
Leishmania major | metacaspase, putative | 0.0122 | 0.0268 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0122 | 0.0268 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0122 | 0.0268 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.011 | 0.0236 | 0.8432 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0407 | 0.0984 | 0.5566 |
Onchocerca volvulus | 0.0675 | 0.1657 | 1 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0675 | 0.1657 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.011 | 0.0236 | 0.8432 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0122 | 0.0268 | 0.013 |
Onchocerca volvulus | 0.0675 | 0.1657 | 1 | |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Onchocerca volvulus | 0.0285 | 0.0677 | 0.3538 | |
Brugia malayi | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Onchocerca volvulus | 0.0675 | 0.1657 | 1 | |
Toxoplasma gondii | cathepsin CPC1 | 0.011 | 0.0236 | 0.8432 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0675 | 0.1657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3995 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0675 | 0.1657 | 0.1538 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Brugia malayi | Carboxylesterase family protein | 0.3995 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0675 | 0.1657 | 0.1657 |
Echinococcus multilocularis | serotonin transporter | 0.0072 | 0.014 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Schistosoma mansoni | hypothetical protein | 0.0285 | 0.0677 | 0.0544 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0675 | 0.1657 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0675 | 0.1657 | 0.1657 |
Brugia malayi | Carboxylesterase family protein | 0.0675 | 0.1657 | 0.1538 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0122 | 0.0268 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3995 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Brugia malayi | Carboxylesterase family protein | 0.0675 | 0.1657 | 0.1538 |
Echinococcus multilocularis | caspase | 0.0122 | 0.0268 | 0.0268 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.011 | 0.0236 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0107 | 0.023 | 0.8096 |
Schistosoma mansoni | gliotactin | 0.0675 | 0.1657 | 0.1538 |
Plasmodium vivax | metacaspase 1, putative | 0.0122 | 0.0268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.0677 | 0.0544 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0675 | 0.1657 | 0.1538 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0122 | 0.0268 | 0.0895 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0675 | 0.1657 | 0.1538 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Trypanosoma brucei | metacaspase 5, putative | 0.0122 | 0.0268 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0122 | 0.0268 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0675 | 0.1657 | 0.1657 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0122 | 0.0268 | 0.0895 |
Echinococcus multilocularis | acetylcholinesterase | 0.3995 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0122 | 0.0268 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 0.1657 | 0.1538 |
Echinococcus granulosus | caspase 8 | 0.0122 | 0.0268 | 0.0268 |
Trypanosoma brucei | metacaspase MCA3 | 0.0122 | 0.0268 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0122 | 0.0268 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0072 | 0.014 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0675 | 0.1657 | 0.1538 |
Brugia malayi | Cell death protein 3 precursor | 0.0407 | 0.0984 | 0.0856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 3.45 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
-Log IC50 (binding) | = 3.45 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 3.45 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
IC50 (binding) | = 3.45 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 3.45 | Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme | ChEMBL. | 9435905 |
Inhibition (binding) | = 14 % | Percent inhibition against bovine Dopamine beta hydroxylase (DBH) at 10E-4 M | ChEMBL. | 3820219 |
Inhibition (binding) | = 14 % | Percent inhibition against bovine Dopamine beta hydroxylase (DBH) at 10E-4 M | ChEMBL. | 3820219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.