Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0082 | 0.0874 | 0.2133 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0874 | 0.2133 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0156 | 0.061 |
Onchocerca volvulus | Dual oxidase homolog | 0.0112 | 0.1498 | 0.166 |
Schistosoma mansoni | peroxidasin | 0.0112 | 0.1498 | 0.3653 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0047 | 0.0156 | 0.0156 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0238 | 0.41 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0047 | 0.0156 | 0.0382 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0112 | 0.1498 | 0.1498 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.015 | 0.2281 | 0.5564 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0047 | 0.0156 | 0.061 |
Brugia malayi | protein kinase C II. | 0.0164 | 0.2566 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0047 | 0.0156 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Brugia malayi | hypothetical protein | 0.0112 | 0.1498 | 0.5836 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0047 | 0.0156 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Schistosoma mansoni | atypical protein kinase C | 0.0081 | 0.0844 | 0.2058 |
Echinococcus granulosus | peroxidasin | 0.0112 | 0.1498 | 0.3653 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.9021 | 0.9021 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0112 | 0.1498 | 0.3653 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.015 | 0.2281 | 0.5564 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0047 | 0.0156 | 0.0156 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0112 | 0.1498 | 0.166 |
Brugia malayi | Animal haem peroxidase family protein | 0.0112 | 0.1498 | 0.5836 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0 | 0.5 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0047 | 0.0156 | 0.0382 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0156 | 0.0382 |
Brugia malayi | Blistered cuticle protein 3 | 0.0112 | 0.1498 | 0.5836 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0112 | 0.1498 | 0.1498 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0047 | 0.0156 | 0.061 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0156 | 0.0382 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0164 | 0.2566 | 0.626 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.9021 | 0.9021 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0047 | 0.0156 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.9021 | 0.9021 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Onchocerca volvulus | 0.0112 | 0.1498 | 0.166 | |
Brugia malayi | Peroxidasin | 0.0112 | 0.1498 | 0.5836 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0047 | 0.0156 | 0.0382 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0083 | 0.0898 | 0.219 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0112 | 0.1498 | 0.1498 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0047 | 0.0156 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0164 | 0.2566 | 0.626 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Echinococcus granulosus | protein kinase c iota type | 0.0081 | 0.0844 | 0.2058 |
Echinococcus multilocularis | protein kinase c iota type | 0.0081 | 0.0844 | 0.2058 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0164 | 0.2566 | 0.2566 |
Onchocerca volvulus | Peroxidasin homolog | 0.0112 | 0.1498 | 0.166 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0047 | 0.0156 | 0.0382 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0112 | 0.1498 | 0.5836 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0082 | 0.0874 | 0.2133 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0047 | 0.0156 | 0.0156 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0047 | 0.0156 | 0.0382 |
Onchocerca volvulus | 0.0112 | 0.1498 | 0.166 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0112 | 0.1498 | 0.5836 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0238 | 0.41 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0047 | 0.0156 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.9708 | 0.9708 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0129 | 0.1849 | 0.4509 |
Brugia malayi | Animal haem peroxidase family protein | 0.0112 | 0.1498 | 0.5836 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0156 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0047 | 0.0156 | 0.0156 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0047 | 0.0156 | 0.0382 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0082 | 0.0874 | 0.2133 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0156 | 0.0382 |
Schistosoma mansoni | lipoxygenase | 0.0238 | 0.41 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0049 | 0.0187 | 0.0457 |
Brugia malayi | Animal haem peroxidase family protein | 0.0112 | 0.1498 | 0.5836 |
Schistosoma mansoni | protein kinase | 0.015 | 0.2281 | 0.5564 |
Brugia malayi | Protein kinase domain containing protein | 0.0047 | 0.0156 | 0.061 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0047 | 0.0156 | 0.0382 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0131 | 0.1884 | 0.7343 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Onchocerca volvulus | Peroxidase homolog | 0.0112 | 0.1498 | 0.166 |
Toxoplasma gondii | AGC kinase | 0.0047 | 0.0156 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0047 | 0.0156 | 0.0156 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0047 | 0.0156 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0047 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0131 | 0.1884 | 0.1884 |
Onchocerca volvulus | Peroxidasin homolog | 0.0112 | 0.1498 | 0.166 |
Schistosoma mansoni | lipoxygenase | 0.0166 | 0.2618 | 0.6387 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0047 | 0.0156 | 0.0382 |
Onchocerca volvulus | 0.0112 | 0.1498 | 0.166 | |
Schistosoma mansoni | protein kinase | 0.015 | 0.2281 | 0.5564 |
Echinococcus granulosus | protein kinase C gamma type | 0.0049 | 0.0187 | 0.0457 |
Schistosoma mansoni | peroxidasin | 0.0112 | 0.1498 | 0.3653 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0047 | 0.0156 | 0.0156 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0164 | 0.2566 | 0.626 |
Schistosoma mansoni | protein kinase | 0.015 | 0.2281 | 0.5564 |
Onchocerca volvulus | 0.0476 | 0.9021 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0112 | 0.1498 | 0.1498 |
Onchocerca volvulus | Peroxidase homolog | 0.0112 | 0.1498 | 0.166 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0083 | 0.0898 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 48 uM | Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation | ChEMBL. | 7783142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.