Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0393 | 0.4968 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.0791 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0843 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0034 | 0.0791 | 0.0791 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0034 | 0.0791 | 0.0791 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.5703 | 0.7126 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.5703 | 0.5703 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0233 | 0.9391 | 0.9674 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.5703 | 0.5703 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.8003 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.4326 | 0.4326 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0034 | 0.0791 | 0.0791 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.5703 | 0.5703 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0034 | 0.0791 | 0.0815 |
Echinococcus multilocularis | jun protein | 0.0247 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0147 | 0.5703 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0843 | 0.0843 |
Plasmodium falciparum | carbonic anhydrase | 0.0034 | 0.0791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0393 | 0.0405 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0843 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0393 | 0.0689 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0843 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0791 | 0.0815 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.9708 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0843 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.5703 | 0.7126 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.4326 | 0.4456 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0034 | 0.0791 | 0.0791 |
Schistosoma mansoni | jun-related protein | 0.02 | 0.8003 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.6417 | 0.6417 |
Brugia malayi | hypothetical protein | 0.0016 | 0.002 | 0.002 |
Brugia malayi | Pax transcription factor protein 2 | 0.0233 | 0.9391 | 0.9391 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0034 | 0.0791 | 0.0988 |
Echinococcus granulosus | jun protein | 0.0247 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0247 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0393 | 0.4968 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0843 | 0.1053 |
Schistosoma mansoni | carbonic anhydrase | 0.0034 | 0.0791 | 0.0988 |
Echinococcus multilocularis | geminin | 0.0164 | 0.6417 | 0.6417 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6417 | 0.8018 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.5703 | 0.5875 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0843 | 0.0843 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0393 | 0.4968 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0034 | 0.0791 | 0.0988 |
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.4326 | 0.4456 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0843 | 0.0843 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0393 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0034 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0791 | 0.0815 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.5703 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.5703 | 0.5875 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.5703 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0843 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0247 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0147 | 0.5703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0791 | 0.0815 |
Brugia malayi | hypothetical protein | 0.0194 | 0.7711 | 0.7711 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0393 | 0.0393 |
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.5703 | 0.5703 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0393 | 0.0689 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0393 | 0.0689 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0034 | 0.0791 | 0.0988 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0791 | 0.0988 |
Echinococcus multilocularis | carbonic anhydrase | 0.0034 | 0.0791 | 0.0791 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0393 | 0.0689 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6417 | 0.8018 |
Onchocerca volvulus | 0.0233 | 0.9391 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2000 nM | In vitro inhibition of purified human erythrocyte carbonic anhydrase II | ChEMBL. | 8340917 |
IC50 (binding) | = 2000 nM | In vitro inhibition of purified human erythrocyte carbonic anhydrase II | ChEMBL. | 8340917 |
pKa (ADMET) | = 9.5 | Acid dissociation constant was determined | ChEMBL. | 8340917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.