Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.8161 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0105 | 1 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.714 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.8161 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.8161 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.8161 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.8161 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.8161 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.8161 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.8161 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.714 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.8161 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.8161 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.8161 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.8161 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.8161 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.8161 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0105 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.8161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.8161 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.8161 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (binding) | = 17 nM | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | ChEMBL. | 12014950 |
IC50 (functional) | = 0.94 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
IC50 (functional) | = 0.94 uM | In vitro secondary T-cell (CEM) proliferation assay | ChEMBL. | 12014950 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12014950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.