Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00333308 | 0.135758 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00106694 | 0.0162883 | 0.0162883 |
Echinococcus granulosus | carboxylesterase 5A | 0.0197264 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00106694 | 0.0162883 | 0.0162883 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00106694 | 0.0162883 | 0.0162883 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.00333308 | 0.135758 | 0.5 |
Onchocerca volvulus | 0.00333308 | 0.135758 | 1 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.00326358 | 0.132093 | 0.132093 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.00333308 | 0.135758 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0197264 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus granulosus | neuroligin | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | carboxylesterase | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.0197264 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus multilocularis | neuroligin | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus multilocularis | acetylcholinesterase | 0.0197264 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0197264 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0197264 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00280096 | 0.107705 | 0.107705 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Brugia malayi | Carboxylesterase family protein | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | carboxylesterase | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00333308 | 0.135758 | 0.135758 |
Brugia malayi | Carboxylesterase family protein | 0.0197264 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus multilocularis | voltage gated potassium channel | 0.00106694 | 0.0162883 | 0.0162883 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00333308 | 0.135758 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0197264 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.00106694 | 0.0162883 | 0.0162883 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0197264 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00333308 | 0.135758 | 0.135758 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00333308 | 0.135758 | 0.135758 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00359815 | 0.149732 | 0.149732 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00106694 | 0.0162883 | 0.0162883 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00326358 | 0.132093 | 0.132093 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.00326358 | 0.132093 | 0.132093 |
Onchocerca volvulus | 0.00333308 | 0.135758 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | carboxylesterase | 0.0197264 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Loa Loa (eye worm) | hypothetical protein | 0.00106694 | 0.0162883 | 0.0162883 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00359815 | 0.149732 | 0.149732 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00326358 | 0.132093 | 0.132093 |
Onchocerca volvulus | 0.00333308 | 0.135758 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0197264 | 1 | 1 |
Onchocerca volvulus | 0.00333308 | 0.135758 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0197264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00333308 | 0.135758 | 0.135758 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00333308 | 0.135758 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.00106694 | 0.0162883 | 0.0162883 |
Brugia malayi | Carboxylesterase family protein | 0.00333308 | 0.135758 | 0.135758 |
Onchocerca volvulus | 0.00333308 | 0.135758 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00333308 | 0.135758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197264 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00333308 | 0.135758 | 0.135758 |
Brugia malayi | Carboxylesterase family protein | 0.00333308 | 0.135758 | 0.135758 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.368 uM | Antiparasitic activity against Plasmodium falciparum K1 | ChEMBL. | 20133138 |
IC50 (functional) | = 5.2 uM | Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 | ChEMBL. | 20133138 |
IC50 (functional) | = 16.3 uM | Antiparasitic activity against Trypanosoma cruzi Tulahuen C2C4 | ChEMBL. | 20133138 |
IC50 (functional) | = 21.2 uM | Antiparasitic activity against Leishmania donovani MHOM-ET-67/L82 axenic amastigotes | ChEMBL. | 20133138 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 20133138 | ||
Trypanosoma cruzi | ChEMBL23 | 20133138 | |
Plasmodium falciparum | 20133138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.