Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0046 | 0.0886 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0579 | 0.1006 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0074 | 0.2128 | 0.1643 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0085 | 0.2614 | 0.4538 |
Mycobacterium ulcerans | thymidylate synthase | 0.0156 | 0.576 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0579 | 0.0351 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0156 | 0.576 | 0.55 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0046 | 0.0886 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0085 | 0.2614 | 0.4538 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0064 | 0.1687 | 0.2929 |
Brugia malayi | hypothetical protein | 0.0074 | 0.2128 | 0.3235 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0579 | 0.0351 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0579 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0044 | 0.0802 | 0.1391 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.576 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0094 | 0.3025 | 0.5251 |
Brugia malayi | thymidylate synthase | 0.0156 | 0.576 | 1 |
Onchocerca volvulus | 0.0156 | 0.576 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0156 | 0.576 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0579 | 0.0351 |
Echinococcus granulosus | thymidylate synthase | 0.0156 | 0.576 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.2128 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0149 | 0.547 | 0.9496 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0035 | 0.0391 | 0.0678 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0579 | 0.0351 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0094 | 0.3025 | 0.5251 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0579 | 0.1006 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0074 | 0.2128 | 0.2988 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0035 | 0.0391 | 0.0678 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0149 | 0.547 | 0.9496 |
Echinococcus granulosus | glutamate receptor 2 | 0.0044 | 0.0802 | 0.1391 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0129 | 0.4584 | 0.781 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0579 | 0.0351 |
Chlamydia trachomatis | glutamine binding protein | 0.0046 | 0.0886 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0579 | 0.0351 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0579 | 0.0351 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0035 | 0.0391 | 0.0678 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0044 | 0.0802 | 0.1391 |
Echinococcus multilocularis | thymidylate synthase | 0.0156 | 0.576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0046 | 0.0886 | 0.0325 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0044 | 0.0802 | 0.1391 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0046 | 0.0886 | 0.0591 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0044 | 0.0802 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0579 | 0.0351 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.576 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0046 | 0.0886 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0156 | 0.576 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39.17 uM | Cytotoxic activity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 19618898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.