Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carboxypeptidase B1 (tissue) | Starlite/ChEMBL | References |
Homo sapiens | carboxypeptidase B2 (plasma) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | subfamily M14A unassigned peptidase | carboxypeptidase B1 (tissue) | 417 aa | 421 aa | 30.6 % |
Loa Loa (eye worm) | hypothetical protein | carboxypeptidase B2 (plasma) | 386 aa | 324 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0072 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0231 | 0.1999 | 0.1999 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0751 | 0.8548 | 0.8548 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.1048 | 0.5 |
Onchocerca volvulus | 0.0505 | 0.5446 | 1 | |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0866 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0515 | 0.0515 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0136 | 0.081 | 0.1487 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.1999 | 0.1999 |
Onchocerca volvulus | 0.0136 | 0.081 | 0.1487 | |
Schistosoma mansoni | alpha-glucosidase | 0.0751 | 0.8548 | 0.8548 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0866 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0751 | 0.8548 | 0.8548 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.2805 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0751 | 0.8548 | 0.8548 |
Onchocerca volvulus | 0.0136 | 0.081 | 0.1487 | |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0866 | 1 | 1 |
Onchocerca volvulus | 0.0136 | 0.081 | 0.1487 | |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.0849 | 0.3028 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 0.2805 | 1 |
Onchocerca volvulus | 0.0136 | 0.081 | 0.1487 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0751 | 0.8548 | 0.8548 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0866 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1999 | 0.1999 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.0849 | 0.3028 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0136 | 0.081 | 0.081 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0136 | 0.081 | 0.081 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.038 | 0.3877 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.2805 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0295 | 0.2805 | 1 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0136 | 0.081 | 0.081 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0751 | 0.8548 | 0.8548 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0072 | 0 | 0.5 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0866 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.038 | 0.3877 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.0849 | 0.3028 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0072 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0751 | 0.8548 | 0.8548 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.1999 | 0.1999 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0072 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLT50 (functional) | = 0.159 uM | Concentration providing 50% acceleration of clot lysis in pooled human plasma | ChEMBL. | 15080996 |
IC50 (binding) | = 0.001 uM | Inhibition of human carboxypeptidase B (CPB) | ChEMBL. | 15080996 |
IC50 (binding) | = 0.001 uM | Inhibition of human carboxypeptidase B (CPB) | ChEMBL. | 15080996 |
IC50 (binding) | = 0.012 uM | Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor) | ChEMBL. | 15080996 |
IC50 (binding) | = 0.012 uM | Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor) | ChEMBL. | 15080996 |
Selectivity (binding) | = 0.08 | Selectivity for TAFIa versus CPB carboxypeptidase B isoforms | ChEMBL. | 15080996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.