Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0658 | 0.0763 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.068 | 0.0789 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0173 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0173 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0173 | 0.018 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0173 | 0.0193 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0173 | 0.0193 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0658 | 0.0493 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0173 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0658 | 0.0493 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0173 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0658 | 0.0763 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.068 | 0.0789 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0173 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0658 | 0.0493 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0173 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0658 | 0.0763 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.068 | 0.0736 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0658 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.9117 | 1 |
Onchocerca volvulus | 0.0047 | 0.068 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8508 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.9117 | 0.9101 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0173 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.001 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.9117 | 0.9101 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0173 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0173 | 0.018 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0173 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.001 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0173 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0658 | 0.0712 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0173 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0658 | 0.0712 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.001 | 0.5 |
Brugia malayi | hypothetical protein | 0.0228 | 0.9117 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | ChEMBL. | 21899292 |
IC50 (functional) | = 0.33 uM | Anticancer activity against human COLO205 cells after 72 hrs by MTS/PMS assay | ChEMBL. | 21899292 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21899292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.