Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calcium channel | 0.0101 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0101 | 1 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0101 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0101 | 1 | 1 |
Echinococcus granulosus | amyloid beta A4 protein | 0.0072 | 0.6392 | 0.6392 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.604 | 0.5401 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0032 | 0.1389 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0101 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1389 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0043 | 0.2717 | 0.2717 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.604 | 0.604 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | X11 protein | 0.0072 | 0.6392 | 0.6392 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.2381 | 0.2381 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.604 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.2381 | 0.1151 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0101 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0101 | 1 | 1 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0032 | 0.1389 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.604 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0043 | 0.2717 | 0.1542 |
Loa Loa (eye worm) | SMO-1 protein | 0.0032 | 0.1389 | 0.1389 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.604 | 0.604 |
Giardia lamblia | Sentrin | 0.0032 | 0.1389 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.604 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.604 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.604 | 0.5401 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0032 | 0.1389 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.6038 | 0.6038 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0101 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.604 | 1 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0032 | 0.1389 | 0.1389 |
Echinococcus multilocularis | amyloid beta A4 protein | 0.0072 | 0.6392 | 0.581 |
Brugia malayi | abnormal cell lineage protein 10 (Protein lin-10), putative | 0.0065 | 0.5437 | 0.4701 |
Schistosoma mansoni | amyloid beta A4 protein related | 0.0072 | 0.6392 | 0.581 |
Brugia malayi | hypothetical protein | 0.0069 | 0.6038 | 0.5399 |
Schistosoma mansoni | voltage-gated cation channel | 0.0101 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0101 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.604 | 0.5401 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0061 | 0.5046 | 0.7862 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0101 | 1 | 1 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0061 | 0.5046 | 0.7862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by broth microdilution assay | ChEMBL. | 20149496 |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 10536 after 24 hrs by broth microdilution assay | ChEMBL. | 20149496 |
MIC (functional) | = 31.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 21 days by broth dilution assay | ChEMBL. | 20149496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.