Detailed view for EgrG_000790600

Basic information

TDR Targets ID: 593889
Echinococcus granulosus, amyloid beta A4 protein
Source Database / ID:  GeneDB

pI: 5.9769 | Length (AA): 838 | MW (Da): 92266 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00640   Phosphotyrosine interaction domain (PTB/PID)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
253 350 2mqa (A) 19 116 12.00 0 0 0.280345 -0.76
418 749 3suz (A) 364 746 45.00 0 1 0.578581 0.65
419 574 4dbb (A) 455 640 35.00 0.0000000025 0.72 0.587158 -0.43
423 543 2m38 (A) 17 144 19.00 0 0.87 0.350791 -0.54
427 543 2dyq (A) 291 410 18.00 0 0.78 0.316018 -0.71
649 746 2yt7 (A) 4 101 55.00 0 1 0.799345 -0.65
654 838 1u3b (A) 17 201 66.00 0 1 1.00016 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130749)

Species Accession Gene Product
Brugia malayi Bm1_00745   abnormal cell lineage protein 10 (Protein lin-10), putative
Brugia malayi Bm1_16370   hypothetical protein
Caenorhabditis elegans CELE_C09H6.2   Protein LIN-10, isoform C
Drosophila melanogaster Dmel_CG32677   CG32677 gene product from transcript CG32677-RE
Drosophila melanogaster Dmel_CG5675   CG5675 gene product from transcript CG5675-RF
Echinococcus granulosus EgrG_000790600   amyloid beta A4 protein
Echinococcus multilocularis EmuJ_000790600   amyloid beta A4 protein
Homo sapiens ENSG00000107282   amyloid beta (A4) precursor protein-binding, family A, member 1
Homo sapiens ENSG00000034053   amyloid beta (A4) precursor protein-binding, family A, member 2
Loa Loa (eye worm) LOAG_07087   hypothetical protein
Loa Loa (eye worm) LOAG_03415   X11 protein
Mus musculus ENSMUSG00000030519   amyloid beta (A4) precursor protein-binding, family A, member 2
Mus musculus ENSMUSG00000024897   amyloid beta (A4) precursor protein binding, family A, member 1
Schistosoma japonicum Sjp_0000950   ko:K04531 amyloid beta (A4) precursor protein-binding, family A, member 1, putative
Schistosoma mansoni Smp_144990   amyloid beta A4 protein related
Schmidtea mediterranea mk4.000384.08  
Schmidtea mediterranea mk4.000384.11  
Schmidtea mediterranea mk4.000384.10  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens amyloid beta (A4) precursor protein-binding, family A, member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0067 0.2736 0.4674
0.0083 0.2715 0.4598
0.0083 0.6392 0.6392
0.0083 0.2819 0.3383
0.007 0.2596 0.6826
0.0083 0.5361 0.6812
0.0067 0.5046 0.5046
0.0067 0.6504 0.6392
0.0082 0.6163 0.5965
0.0072 0.6392 0.6392
0.0078 0.2675 0.6812
0.0083 0.2503 0.3559
0.0074 0.3891 0.4022
0.0083 0.3836 0.3788
0.0083 0.6392 0.6392
0.0083 0.6392 0.6392
0.0083 0.2514 0.5179
0.0122 0.2749 0.2794
0.0135 0.2644 0.3215
0.0073 0.2508 0.2508
0.0204 0.2898 0.289
0.0083 0.6859 0.6859
0.0083 0.2583 0.5942

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000790600 (Echinococcus granulosus), amyloid beta A4 protein
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