Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | CLC chloride channel protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0076 | 0.023 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.0462 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.0472 | 0.1761 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.0425 | 0.1582 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | GMP reductase | 0.0184 | 0.0995 | 0.3826 |
Onchocerca volvulus | 0.0041 | 0.0109 | 0.1096 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0109 | 0.0419 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0041 | 0.0109 | 0.1096 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0041 | 0.0109 | 0.0358 |
Schistosoma mansoni | coup transcription factor | 0.0041 | 0.0109 | 0.0358 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0417 | 0.2437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.1446 | 0.5559 |
Treponema pallidum | hemolysin (tlyC) | 0.0026 | 0.0017 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0263 | 0.1482 | 0.1468 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0093 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0093 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | steroid hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0304 | 0.1738 | 0.1724 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0443 | 0.2601 | 1 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0026 | 0.0017 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0.1738 | 0.6662 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0443 | 0.2601 | 1 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0443 | 0.2601 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0462 | 0.1777 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0041 | 0.0109 | 0.0419 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0115 | 0.038 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0017 | 0.0064 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0109 | 0.0093 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0115 | 0.038 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0041 | 0.0109 | 0.0358 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Voltage gated chloride channel family protein | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0041 | 0.0109 | 0.0419 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0184 | 0.0995 | 0.3826 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.146 | 0.5615 |
Loa Loa (eye worm) | chloride channel protein 7 | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0233 | 0.1296 | 0.4983 |
Brugia malayi | nuclear hormone receptor | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0109 | 0.0358 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0041 | 0.0109 | 0.0093 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.0462 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0076 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0173 | 0.0667 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | CBS domain containing protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.021 | 0.1158 | 0.4454 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Treponema pallidum | Mg2+ transport protein (mgtE) | 0.0026 | 0.0017 | 0.5 |
Leishmania major | chloride channel protein, putative | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0233 | 0.1296 | 0.4983 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0115 | 0.0441 |
Mycobacterium ulcerans | transcriptional regulator | 0.0026 | 0.0017 | 0.0064 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0279 | 0.1581 | 0.6079 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.0462 | 0.1724 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0041 | 0.0109 | 0.1096 |
Onchocerca volvulus | 0.0026 | 0.0017 | 0.0166 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0109 | 0.0419 |
Trypanosoma cruzi | GMP reductase | 0.0443 | 0.2601 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0443 | 0.2601 | 0.2588 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.0425 | 0.0409 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0109 | 0.0419 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0026 | 0.0017 | 0.0064 |
Trypanosoma brucei | GMP reductase | 0.0443 | 0.2601 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.0462 | 0.1777 |
Onchocerca volvulus | Putative GMP reductase | 0.0184 | 0.0995 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0443 | 0.2601 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0417 | 0.2437 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane alanine and leucine rich protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0076 | 0.023 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0115 | 0.0098 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0041 | 0.0109 | 0.1096 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0041 | 0.0109 | 0.0358 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0115 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0109 | 0.0419 |
Chlamydia trachomatis | GutQ/KpsF family sugar-phosphate isomerase | 0.0026 | 0.0017 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0263 | 0.1482 | 0.5673 |
Loa Loa (eye worm) | chloride channel 3 | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0443 | 0.2601 | 1 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0026 | 0.0017 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0041 | 0.0109 | 0.0358 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0184 | 0.0995 | 0.3826 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.014 | 0.0723 | 0.0708 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0109 | 0.0093 |
Toxoplasma gondii | IMP dehydrogenas | 0.0443 | 0.2601 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0443 | 0.2601 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0105 | 0.0343 |
Leishmania major | chloride channel protein, putative | 0.0026 | 0.0017 | 0.0064 |
Trypanosoma cruzi | GMP reductase | 0.0443 | 0.2601 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0109 | 0.0419 |
Giardia lamblia | Hypothetical protein | 0.0026 | 0.0017 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0152 | 0.0135 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0115 | 0.0441 |
Brugia malayi | ecdysteroid receptor | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0109 | 0.0093 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0076 | 0.0059 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | nuclear hormone receptor | 0.0041 | 0.0109 | 0.0358 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0115 | 0.038 |
Leishmania major | CBS domain protein, conserved | 0.0026 | 0.0017 | 0.0064 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | loechrig isoform VII | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0109 | 0.0419 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0041 | 0.0109 | 0.0093 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0076 | 0.1641 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0115 | 0.0098 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0041 | 0.0109 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0115 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Giardia lamblia | Manganese-dependent inorganic pyrophosphatase, putative | 0.0026 | 0.0017 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0443 | 0.2601 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.021 | 0.1158 | 0.4454 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0076 | 0.023 |
Mycobacterium tuberculosis | Hypoxic response protein 1 Hrp1 | 0.0026 | 0.0017 | 0.0064 |
Chlamydia trachomatis | Mg++ transporter | 0.0026 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0109 | 0.0419 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.014 | 0.0723 | 0.2735 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Brugia malayi | chloride channel protein 7 | 0.0026 | 0.0017 | 0.0064 |
Loa Loa (eye worm) | GMP reductase | 0.0184 | 0.0995 | 0.3826 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Chlamydia trachomatis | CBS domain-containing protein | 0.0026 | 0.0017 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | ancient conserved domain protein 4 | 0.0026 | 0.0017 | 0.0064 |
Schistosoma mansoni | thyroid hormone receptor | 0.0304 | 0.1738 | 0.6662 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0041 | 0.0109 | 0.0358 |
Brugia malayi | nuclear receptor NHR-88 | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.1482 | 0.5673 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0041 | 0.0109 | 0.0358 |
Mycobacterium tuberculosis | Conserved protein | 0.0026 | 0.0017 | 0.0064 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0417 | 0.2437 | 0.9373 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0109 | 0.0419 |
Brugia malayi | ancient conserved domain protein 2 | 0.0026 | 0.0017 | 0.0064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.