Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Onchocerca volvulus | 0.0218 | 0.071 | 0.5204 | |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Brugia malayi | SWIRM domain containing protein | 0.0244 | 0.1021 | 0.2508 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0612 | 0.5302 | 0.53 |
Onchocerca volvulus | 0.0273 | 0.136 | 1 | |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0263 | 0.1235 | 0.2454 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0263 | 0.1235 | 0.1465 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0445 | 0.3354 | 0.335 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.1292 |
Echinococcus multilocularis | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Echinococcus granulosus | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0005 | 0.001 |
Brugia malayi | Trypsin family protein | 0.0273 | 0.136 | 0.3345 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0462 | 0.3549 | 0.7049 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0157 | 0.0005 | 0.001 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0433 | 0.3216 | 0.3824 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0505 | 0.4056 | 1 |
Onchocerca volvulus | 0.0244 | 0.1021 | 0.7498 | |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0462 | 0.3549 | 0.422 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.036 | 0.237 | 0.5838 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | glutamate receptor kainate | 0.0462 | 0.3549 | 0.422 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Chlamydia trachomatis | glutamate symporter | 0.0263 | 0.1235 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.0528 | 0.105 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0452 | 0.3438 | 0.4088 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.0263 | 0.1235 | 0.908 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0445 | 0.3354 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.0255 | 0.1842 | |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0306 | 0.1742 | 0.5186 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0445 | 0.3354 | 0.3987 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0505 | 0.4056 | 0.8056 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0528 | 0.105 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.666 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0263 | 0.1235 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.0263 | 0.1235 | 0.1987 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Brugia malayi | thymidylate synthase | 0.0218 | 0.071 | 0.1741 |
Brugia malayi | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.3037 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.105 |
Loa Loa (eye worm) | thymidylate synthase | 0.0218 | 0.071 | 0.1411 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0445 | 0.3354 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | proteasome prosome macropain | 0.0445 | 0.3354 | 0.335 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0167 | 0.0119 | 0.0237 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0445 | 0.3354 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.042 | 0.0834 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0498 | 0.3967 | 0.978 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0505 | 0.4056 | 1 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0196 | 0.0455 | 0.3319 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Echinococcus granulosus | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | NMDA receptor | 0.0612 | 0.5302 | 0.53 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0734 | 0.672 | 0.6718 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0294 | 0.1597 | 0.3929 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0225 | 0.08 | 0.0946 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0505 | 0.4056 | 0.4053 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.5035 | 1 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.0448 | 0.0528 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Echinococcus granulosus | neutral amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0294 | 0.1597 | 0.1895 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0445 | 0.3354 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.8266 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0218 | 0.071 | 0.084 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0462 | 0.3549 | 0.422 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0498 | 0.3967 | 0.7878 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Mycobacterium ulcerans | proteasome PrcB | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.1021 | 0.2028 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0599 | 0.5146 | 0.6122 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0445 | 0.3354 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 188 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
IC50 (binding) | = 188 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.