Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0136 | 0.1655 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0235 | 0.3667 | 1 |
Onchocerca volvulus | 0.0175 | 0.2451 | 0.9924 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0235 | 0.3667 | 0.3667 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2069 | 0.2069 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0235 | 0.3667 | 1 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0136 | 0.1655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.3667 | 0.3667 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0136 | 0.1655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1465 | 0.1465 |
Brugia malayi | Carboxylesterase family protein | 0.0235 | 0.3667 | 0.3667 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 1 | 1 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0136 | 0.1655 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0.1655 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.1655 | 0.1911 | |
Loa Loa (eye worm) | carboxylesterase | 0.0235 | 0.3667 | 0.3667 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0136 | 0.1655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.3667 | 0.3667 |
Echinococcus granulosus | acetylcholinesterase | 0.0235 | 0.3667 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0235 | 0.3667 | 1 |
Brugia malayi | hypothetical protein | 0.0157 | 0.2069 | 0.2069 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.8175 | 0.8175 |
Brugia malayi | hypothetical protein | 0.0127 | 0.1465 | 0.1465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0235 | 0.3667 | 1 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0136 | 0.1655 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0235 | 0.3667 | 0.3667 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0235 | 0.3667 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0235 | 0.3667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1465 | 0.1465 |
Onchocerca volvulus | 0.0176 | 0.2459 | 1 | |
Onchocerca volvulus | 0.0157 | 0.2069 | 0.6075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 53 nM | Inhibition of ROCK2 | ChEMBL. | 19837589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.