Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0133 | 0.9021 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7304 | 0.8089 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0133 | 0.9021 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8538 | 0.9462 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5841 | 0.6463 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0082 | 0.4009 | 0.4425 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0133 | 0.9021 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0133 | 0.9021 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0133 | 0.9021 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0031 | 0.0035 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0133 | 0.9021 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0133 | 0.9021 | 0.9018 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0133 | 0.9021 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0133 | 0.9021 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0133 | 0.9021 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0.0031 | 0.0035 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0133 | 0.9021 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40 nM | Inhibition of [3H]-Leu-enkephalin binding to Aminopeptidase N from hog kidney | ChEMBL. | 1348542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.