Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA polymerase eta | 0.005 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.005 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3151 | 0.3151 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.3151 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.6422 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.3151 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.3151 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.3151 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3151 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.3151 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0035 | 0.6422 | 0.4775 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.3151 | 0.3151 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3151 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.3151 | 0.3151 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.3151 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.3151 | 0.3151 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0035 | 0.6422 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3151 | 0.3151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 67 nM | Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay | ChEMBL. | 20446681 |
EC50 (binding) | = 189 nM | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay | ChEMBL. | 20446681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.