Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | cathepsin B | 339 aa | 368 aa | 26.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 0.9932 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.259 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.9932 | 0.9932 |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.259 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.259 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1191 | 0.1199 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2218 | 0.2233 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.259 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0166 | 0.9932 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2218 | 0.2233 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.9932 | 0.9932 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.259 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.9932 | 0.9932 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.9932 | 0.9932 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 0.9932 | 0.9932 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.259 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.259 | 0.259 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.259 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2218 | 0.2233 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.9932 | 0.9932 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0055 | 0.259 | 0.2606 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0002 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0002 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.259 | 0.2608 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2218 | 0.2233 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.9932 | 0.9932 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.9932 | 0.9932 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0002 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1191 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.9932 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1191 | 0.1191 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 0.2 | Inhibition of human recombinant cathepsin B assessed as factor by which the product formation changes when the inhibitor binds to the enzyme-substrate complex using Z-Arg-Arg-AMC as substrate by fluorescence microplate assay | ChEMBL. | 21849222 |
IC50 (binding) | > 1000 uM | Inhibition of human DNA topoisomerase IIalpha using plasmid pNO1 as a substrate after 30 mins | ChEMBL. | 26183545 |
Inhibition (binding) | Inhibition of human liver cathepsin H expressed in Escherichia coli assessed as formation of fluorescent degradation product AMC using Arg-AMC as substrate at 50 uM by fluorescence microplate assay | ChEMBL. | 21849222 | |
Inhibition (binding) | Inhibition of human recombinant cathepsin L expressed in Escherichia coli assessed as formation of fluorescent degradation product AMC using Z-Phe-Arg-AMC as substrate at 50 uM by fluorescence microplate assay | ChEMBL. | 21849222 | |
Ki (binding) | = 10.3 uM | Partial mixed-type inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as substrate by Michaelis-Menten method | ChEMBL. | 21849222 |
Ki (binding) | = 11.1 uM | Reversible inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as substrate by Michaelis-Menten method | ChEMBL. | 21849222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.