Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Protein patched homolog 1 | 0.0304 | 0.3747 | 0.3711 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0737 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0304 | 0.3747 | 0.2464 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0737 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0304 | 0.3747 | 0.3711 |
Echinococcus multilocularis | protein dispatched 1 | 0.0304 | 0.3747 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.3747 | 0.2464 |
Brugia malayi | CHE-14 protein | 0.0304 | 0.3747 | 0.2464 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0304 | 0.3747 | 0.2464 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0737 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0304 | 0.3747 | 0.3711 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0304 | 0.3747 | 0.2464 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0737 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0346 | 0.4358 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0304 | 0.3747 | 0.858 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0346 | 0.4358 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0737 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0346 | 0.4358 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.0057 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0157 | 0.1637 | 0.1589 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0737 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0304 | 0.3747 | 0.2464 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0304 | 0.3747 | 0.2464 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0346 | 0.4358 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0737 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0737 | 1 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.0057 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0304 | 0.3747 | 0.2464 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 6 % | Percent displacement from adenosine A2 receptor at 10e-7 M in rat striatal membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 47 % | Percent displacement from adenosine A1 receptor at 10e-7 M in rat brain membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 82 % | Percent displacement from adenosine A2 receptor at 10e-5 M in rat striatal membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 100 % | Percent displacement from adenosine A1 receptor at 10e-5 M in rat brain membrane in vitro. | ChEMBL. | 7996542 |
ED50 (functional) | = 26.2 mg kg-1 | Effective dose for phenylbenzoquinone-induced writhing in mice after peroral administration expressed as analgesic activity. | ChEMBL. | 7996542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.