Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | 0.0505 | 0.4056 | 1 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.105 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0157 | 0.0005 | 0.001 |
Schistosoma mansoni | glutamate receptor kainate | 0.0462 | 0.3549 | 0.422 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0505 | 0.4056 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0445 | 0.3354 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0244 | 0.1021 | 0.2508 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0263 | 0.1235 | 0.2454 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.036 | 0.237 | 0.5838 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0433 | 0.3216 | 0.3824 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0196 | 0.0455 | 0.3319 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0445 | 0.3354 | 0.335 |
Brugia malayi | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.3037 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Onchocerca volvulus | 0.0218 | 0.071 | 0.5204 | |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Brugia malayi | thymidylate synthase | 0.0218 | 0.071 | 0.1741 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.666 |
Brugia malayi | Trypsin family protein | 0.0273 | 0.136 | 0.3345 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0734 | 0.672 | 0.6718 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0599 | 0.5146 | 0.6122 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0445 | 0.3354 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0218 | 0.071 | 0.1411 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0462 | 0.3549 | 0.7049 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0528 | 0.105 |
Onchocerca volvulus | 0.0178 | 0.0255 | 0.1842 | |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.042 | 0.0834 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0505 | 0.4056 | 0.8056 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Echinococcus multilocularis | NMDA receptor | 0.0612 | 0.5302 | 0.53 |
Echinococcus granulosus | proteasome prosome macropain | 0.0445 | 0.3354 | 0.335 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0445 | 0.3354 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0263 | 0.1235 | 0.1465 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0225 | 0.08 | 0.0946 |
Loa Loa (eye worm) | glutamate receptor | 0.0498 | 0.3967 | 0.7878 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0445 | 0.3354 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.0448 | 0.0528 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0452 | 0.3438 | 0.4088 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0167 | 0.0119 | 0.0237 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.0263 | 0.1235 | 0.1987 |
Mycobacterium ulcerans | proteasome PrcB | 0.0445 | 0.3354 | 1 |
Chlamydia trachomatis | glutamate symporter | 0.0263 | 0.1235 | 0.5 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0445 | 0.3354 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0005 | 0.001 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0294 | 0.1597 | 0.3929 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0294 | 0.1597 | 0.1895 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Echinococcus granulosus | neutral amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Onchocerca volvulus | 0.0244 | 0.1021 | 0.7498 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.8266 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.1021 | 0.2028 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0612 | 0.5302 | 0.53 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0462 | 0.3549 | 0.422 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0498 | 0.3967 | 0.978 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Onchocerca volvulus | 0.0273 | 0.136 | 1 | |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.0263 | 0.1235 | 0.908 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Echinococcus granulosus | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0505 | 0.4056 | 0.4053 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.5035 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0462 | 0.3549 | 0.422 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0263 | 0.1235 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.1292 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0218 | 0.071 | 0.084 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0306 | 0.1742 | 0.5186 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0445 | 0.3354 | 0.3987 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.0528 | 0.105 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0445 | 0.3354 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
IC50 (binding) | = 100 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.