Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0157 | 0.0005 | 0.001 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0734 | 0.672 | 0.6718 |
Loa Loa (eye worm) | thymidylate synthase | 0.0218 | 0.071 | 0.1411 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0462 | 0.3549 | 0.422 |
Echinococcus multilocularis | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.0263 | 0.1235 | 0.1987 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.666 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0445 | 0.3354 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0599 | 0.5146 | 0.6122 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0005 | 0.001 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Echinococcus granulosus | glutamate receptor 2 | 0.0448 | 0.3386 | 0.3383 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0445 | 0.3354 | 0.8266 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Onchocerca volvulus | 0.0244 | 0.1021 | 0.7498 | |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.0263 | 0.1235 | 0.5 |
Echinococcus granulosus | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Chlamydia trachomatis | glutamate symporter | 0.0263 | 0.1235 | 0.5 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Brugia malayi | thymidylate synthase | 0.0218 | 0.071 | 0.1741 |
Echinococcus granulosus | thymidylate synthase | 0.0218 | 0.071 | 0.0706 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0306 | 0.1742 | 0.5186 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0239 | 0.0955 | 0.095 |
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0167 | 0.0119 | 0.0237 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.0263 | 0.1235 | 0.1465 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | glutamate receptor | 0.0498 | 0.3967 | 0.7878 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.0263 | 0.1235 | 0.2454 |
Brugia malayi | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.3037 |
Brugia malayi | SWIRM domain containing protein | 0.0244 | 0.1021 | 0.2508 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0445 | 0.3354 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0452 | 0.3438 | 0.4088 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0445 | 0.3354 | 0.3987 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0433 | 0.3216 | 0.3824 |
Echinococcus granulosus | neutral amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.1292 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0498 | 0.3967 | 0.978 |
Echinococcus multilocularis | NMDA receptor | 0.0612 | 0.5302 | 0.53 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.036 | 0.237 | 0.5838 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0202 | 0.0528 | 0.105 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.042 | 0.0834 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0505 | 0.4056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.08 | 0.1588 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0273 | 0.136 | 0.1614 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Onchocerca volvulus | 0.0178 | 0.0255 | 0.1842 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0225 | 0.08 | 0.0795 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 0.5035 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0879 | 0.8403 | 1 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.136 | 0.2701 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.0263 | 0.1235 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.1021 | 0.2028 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Echinococcus granulosus | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0505 | 0.4056 | 0.8056 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Onchocerca volvulus | 0.0218 | 0.071 | 0.5204 | |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0196 | 0.0455 | 0.3319 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0445 | 0.3354 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0505 | 0.4056 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0294 | 0.1597 | 0.3929 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0505 | 0.4056 | 0.4053 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0462 | 0.3549 | 0.3546 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0225 | 0.08 | 0.0946 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1017 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0445 | 0.3354 | 0.335 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0528 | 0.105 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0445 | 0.3354 | 0.335 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0445 | 0.3354 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0294 | 0.1597 | 0.1895 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0195 | 0.0448 | 0.0443 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0612 | 0.5302 | 0.53 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.0448 | 0.0528 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.0528 | 0.105 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0643 | 0.5653 | 0.5651 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1017 | 1 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0462 | 0.3549 | 0.422 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0643 | 0.5653 | 0.5651 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0462 | 0.3549 | 0.422 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0317 | 0.1866 | 0.1862 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.059 | 0.5035 | 0.5033 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0218 | 0.071 | 0.084 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.0263 | 0.1235 | 0.1231 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0433 | 0.3216 | 0.3213 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0462 | 0.3549 | 0.7049 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.0263 | 0.1235 | 0.1231 |
Onchocerca volvulus | 0.0273 | 0.136 | 1 | |
Brugia malayi | Trypsin family protein | 0.0273 | 0.136 | 0.3345 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0445 | 0.3354 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0306 | 0.1742 | 0.5186 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0445 | 0.3354 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0462 | 0.3549 | 0.422 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0445 | 0.3354 | 1 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.0263 | 0.1235 | 0.1231 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.0263 | 0.1235 | 0.908 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0612 | 0.5302 | 0.53 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0445 | 0.3354 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
IC50 (binding) | = 100 uM | Inhibitory activity against recombinant human adenylate cyclase 5 expressed in HEK293 cells. | ChEMBL. | 12747789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.