TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.374 | Formula: C19H22O7
H donors: 4 H acceptors: 4 LogP: 1.36 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H](Oc2ccc(cc2)c2ccccc2OC)[C@H]([C@H]([C@@H]1O)O)O
InChi: 1S/C19H22O7/c1-24-14-5-3-2-4-13(14)11-6-8-12(9-7-11)25-19-18(23)17(22)16(21)15(10-20)26-19/h2-9,15-23H,10H2,1H3/t15-,16-,17+,18+,19+/m1/s1
InChiKey: MSHGAWSCFOIOGE-GFEQUFNTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	importin beta, putative	0.0031	0.0307	0.0198
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.1817	0.1817
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0372	0.0372
Schistosoma mansoni	CD36-like class B scavenger receptor	0.012	0.205	0.205
Loa Loa (eye worm)	cytochrome P450 family protein	0.0056	0.08	0.08
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.1817	0.1817
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0192	0.0099
Schistosoma mansoni	glutaminase	0.0528	1	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.2938	0.3466
Brugia malayi	hypothetical protein	0.0176	0.3126	0.3126
Leishmania major	GTP-binding protein, putative	0.0023	0.0147	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0316	0.0316
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0316	0.059
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.1148	0.1148
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0324	0.8034
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0372	0.0541
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0324	0.0231
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0906	0.1317
Schistosoma mansoni	ran	0.0023	0.0147	0.0147
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0083	0.0911
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0304	0.0441
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0403	1
Plasmodium falciparum	protein kinase 6	0.0436	0.8199	1
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3126	0.3126
Loa Loa (eye worm)	hypothetical protein	0.012	0.205	0.205
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0324	0.8034
Echinococcus granulosus	CD36 class B scavenger receptor	0.012	0.205	0.2979
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0403	0.0318
Echinococcus multilocularis	transfer RNA-Lys	0.0039	0.0458	0.0666
Echinococcus granulosus	CD36 class B scavenger receptor	0.012	0.205	0.2979
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0372	0.0541
Schistosoma mansoni	glucose transport protein	0.0103	0.1705	0.1705
Trypanosoma cruzi	hexose transporter	0.0032	0.0324	0.8034
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Echinococcus granulosus	CD36 class B scavenger receptor	0.012	0.205	0.2979
Schistosoma mansoni	hypothetical protein	0.0034	0.0372	0.0372
Schistosoma mansoni	hypothetical protein	0.0034	0.0372	0.0372
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0403	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0062	0.0906	0.0906
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.015	0.0172
Echinococcus multilocularis	lysosome membrane protein 2	0.012	0.205	0.2979
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0316	0.059
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0192	0.4772
Onchocerca volvulus	Lysosome membrane protein 2 homolog	0.012	0.205	0.6406
Loa Loa (eye worm)	hypothetical protein	0.0045	0.059	0.059
Schistosoma mansoni	cd36 antigen	0.0045	0.059	0.059
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Brugia malayi	PAS domain containing protein	0.0052	0.0723	0.0723
Echinococcus granulosus	General substrate transporter	0.0088	0.1423	0.2068
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0192	0.0099
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0316	0.7839
Brugia malayi	hypothetical protein	0.0166	0.2943	0.2943
Schistosoma mansoni	ran	0.0023	0.0147	0.0147
Echinococcus granulosus	snurportin 1	0.033	0.6145	0.8929
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0372	0.0541
Schistosoma mansoni	glucose transport protein	0.0103	0.1705	0.1705
Onchocerca volvulus		0.0166	0.2943	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0007	0.0162
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0278	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0324	0.0231
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0278	0.0404
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0147	0.0275
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0324	0.0231
Echinococcus multilocularis	CD36 class B scavenger receptor	0.012	0.205	0.2979
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0304	0.0211
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0316	0.059
Leishmania major	glucose transporter, lmgt2	0.0032	0.0324	0.3574
Schistosoma mansoni	importin beta-1	0.0031	0.0307	0.0307
Schistosoma mansoni	scavenger receptor class B type-2 (sr-B2)	0.012	0.205	0.205
Schistosoma mansoni	glucose transport protein	0.0103	0.1705	0.1705
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0307	0.0572
Echinococcus multilocularis	CD36 class B scavenger receptor	0.012	0.205	0.2979
Echinococcus granulosus	geminin	0.0368	0.6882	1
Schistosoma mansoni	hypothetical protein	0.0368	0.6882	0.6882
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.2938	0.5482
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0162	0.2861	0.2861
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0307	0.7603
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0316	0.021
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Echinococcus granulosus	CD36 class B scavenger receptor	0.012	0.205	0.2979
Loa Loa (eye worm)	glutaminase 2	0.0528	1	1
Echinococcus multilocularis	geminin	0.0368	0.6882	1
Brugia malayi	CD36 family protein	0.012	0.205	0.205
Schistosoma mansoni	protein kinase	0.0031	0.0316	0.0316
Brugia malayi	bHLH-PAS transcription factor	0.0039	0.0458	0.0458
Schistosoma mansoni	CD36-like class B scavenger receptor	0.012	0.205	0.205
Loa Loa (eye worm)	glutaminase	0.0528	1	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Echinococcus multilocularis	General substrate transporter	0.0088	0.1423	0.2068
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1148	0.1148
Schistosoma mansoni	hypothetical protein	0.033	0.6145	0.6145
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0058	0.0825	0.0825
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Trichomonas vaginalis	glutaminase, putative	0.0528	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0372	0.0372
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0307	0.0198
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0304	0.0304
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0147	0.0147
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0083	0.2719
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0147	0.3651
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.015	0.0218
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0304	1
Echinococcus multilocularis	CD36 class B scavenger receptor	0.012	0.205	0.2979
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0062	0.0906	0.0906
Leishmania major	glucose transporter, lmgt1	0.0032	0.0324	0.3574
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.015	0.4937
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0307	0.0445
Brugia malayi	Sugar transporter family protein	0.0103	0.1705	0.1705
Schistosoma mansoni	hypothetical protein	0.0074	0.1148	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0307	0.0307
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0324	0.0231
Echinococcus multilocularis	snurportin 1	0.033	0.6145	0.8929
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0316	0.0316
Leishmania major	protein kinase, putative	0.0016	0.0007	0.0072
Mycobacterium ulcerans	putative regulatory protein	0.0039	0.0458	0.0458
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Schistosoma mansoni	aryl hydrocarbon receptor	0.0052	0.0723	0.0723
Schistosoma mansoni	single-minded	0.0052	0.0723	0.0723
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0372	0.0372
Schistosoma mansoni	protein kinase	0.0031	0.0316	0.0316
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0324	0.0231
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0372	0.0541
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0147	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0045	0.059	0.059
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0403	1
Echinococcus granulosus	single minded 2	0.0039	0.0458	0.0666
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0304	0.0441
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0324	0.3574
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0324	0.0231
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0324	0.0231
Echinococcus multilocularis	CD36 class B scavenger receptor	0.012	0.205	0.2979
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0403	0.0318
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0147	0.3651
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0147	0.3651
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0307	0.7603
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0316	0.0316
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0007	0.0162
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0906	0.1317
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0316	0.0316
Brugia malayi	hypothetical protein	0.0045	0.059	0.059
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.015	0.015
Brugia malayi	hypoxia-induced factor 1	0.0162	0.2861	0.2861
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0324	0.8034
Schistosoma mansoni	protein kinase	0.0031	0.0316	0.0316
Echinococcus multilocularis	CD36 class B scavenger receptor	0.012	0.205	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0372	0.0372
Leishmania major	protein kinase, putative	0.0031	0.0316	0.3487
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.015	0.015
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0007	0.0162
Brugia malayi	Importin beta-1 subunit	0.0031	0.0307	0.0307
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Plasmodium vivax	hexose transporter	0.0103	0.1705	0.1935
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1817	0.1817
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0307	0.0445
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.1817	0.1817
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0403	0.0752
Entamoeba histolytica	protein kinase, putative	0.0031	0.0316	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0304	0.9265
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.015	0.1654
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Schistosoma mansoni	hypothetical protein	0.0103	0.1705	0.1705
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0316	0.021
Loa Loa (eye worm)	sugar transporter	0.0103	0.1705	0.1705
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.015	0.0218
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Brugia malayi	Cam kinase protein 1	0.0031	0.0316	0.0316
Entamoeba histolytica	protein kinase, putative	0.0031	0.0316	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0316	0.0459
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0324	0.8034
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.015	0.3718
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0316	0.021
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0403	0.4448
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0045	0.059	0.059
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0062	0.0906	1
Brugia malayi	Cytochrome P450 family protein	0.0056	0.08	0.08
Plasmodium falciparum	protein kinase 7	0.029	0.5358	0.6472
Echinococcus granulosus	GPCR family 2	0.0034	0.0372	0.0541
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.015	0.0056
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.015	0.015
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0304	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0372	0.0372
Echinococcus granulosus	lysosome membrane protein 2	0.012	0.205	0.2979
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0316	0.021
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0304	0.0304
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.2938	0.3466
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0042	0.1053
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.015	0.5
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.015	0.0003
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.033	0.6145	0.6145
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0316	0.021
Brugia malayi	RNA, U transporter 1	0.0088	0.1419	0.1419
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0316	0.021
Schistosoma mansoni	hypothetical protein	0.0034	0.0372	0.0372
Mycobacterium ulcerans	glutaminase	0.0528	1	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0192	0.2677
Loa Loa (eye worm)	hypothetical protein	0.012	0.205	0.205
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.015	0.015
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0324	0.8034
Leishmania major	glucose transporter, lmgt3	0.0032	0.0324	0.3574
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0324	0.8034
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0403	0.4448
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0147	0.0214
Schistosoma mansoni	hypothetical protein	0.0368	0.6882	0.6882
Loa Loa (eye worm)	hypothetical protein	0.012	0.205	0.205
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0192	0.0099
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0083	0.0911
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.015	0.028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0191	0.0191
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0436	0.8199	1
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.015	0.0003
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0324	0.8034
Entamoeba histolytica	hypothetical protein	0.0023	0.015	0.0159
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0304	0.0304
Plasmodium falciparum	hexose transporter	0.0103	0.1705	0.1935
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.015	0.015
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.1705	0.2477
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.015	0.3718
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0007	0.0162
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0316	0.0223
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0304	0.0304
Leishmania major	protein kinase, putative	0.0016	0.0007	0.0072
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0324	0.8034
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0316	0.0316
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0316	0.021
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0304	0.0304
Toxoplasma gondii	protein kinase, putative	0.029	0.5358	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0324	0.8034
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0062	0.0906	1
Trichomonas vaginalis	ran, putative	0.0023	0.0147	0.0053
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0316	0.021
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0316	0.021
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0023	0.015	0.015
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0192	0.2123
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0372	0.0541
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.1705	0.2477
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.0906	0.0906
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0316	0.0459
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.1705	0.3181
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.1705	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0166	0.2943	0.2943
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0045	0.059	0.059
Echinococcus granulosus	CD36 class B scavenger receptor	0.012	0.205	0.2979
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.0906	0.0906

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1171474

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1142517