Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | GHMP kinase, N-terminal domain-containing protein | 0.0178 | 0.2636 | 0.5 |
Trichomonas vaginalis | diphosphomevalonate decarboxylase, putative | 0.0388 | 1 | 1 |
Trypanosoma cruzi | mevalonate kinase, putative | 0.0178 | 0.2636 | 0.2636 |
Onchocerca volvulus | 0.0388 | 1 | 0.5 | |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0178 | 0.2636 | 0.5 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Schistosoma mansoni | diphosphomevalonate decarboxylase | 0.0388 | 1 | 1 |
Trypanosoma cruzi | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0388 | 1 | 1 |
Leishmania major | mevalonate-diphosphate decarboxylase, putative | 0.0388 | 1 | 1 |
Echinococcus granulosus | diphosphomevalonate decarboxylase | 0.0388 | 1 | 1 |
Trypanosoma brucei | mevalonate-diphosphate decarboxylase | 0.0388 | 1 | 1 |
Entamoeba histolytica | galactokinase, putative | 0.0178 | 0.2636 | 0.5 |
Mycobacterium tuberculosis | Probable galactokinase GalK (galactose kinase) | 0.0178 | 0.2636 | 0.5 |
Trypanosoma brucei | mevalonate diphosphate decarboxylase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.7364 | 1 |
Echinococcus multilocularis | diphosphomevalonate decarboxylase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Possible D-alpha-D-heptose-7-phosphate kinase HddA | 0.0178 | 0.2636 | 0.5 |
Trypanosoma cruzi | mevalonate-diphosphate decarboxylase, putative | 0.0388 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0178 | 0.2636 | 0.5 |
Loa Loa (eye worm) | diphosphomevalonate decarboxylase | 0.0313 | 0.7364 | 1 |
Trypanosoma cruzi | homoserine kinase | 0.0178 | 0.2636 | 0.2636 |
Trichomonas vaginalis | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Toxoplasma gondii | GHMP kinase, putative | 0.0178 | 0.2636 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0178 | 0.2636 | 1 |
Giardia lamblia | Diphosphomevalonate decarboxylase | 0.0388 | 1 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0178 | 0.2636 | 0.2636 |
Trypanosoma cruzi | homoserine kinase | 0.0178 | 0.2636 | 0.2636 |
Mycobacterium ulcerans | diphosphomevalonate decarboxylase | 0.0388 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.