Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0707 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.125 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.125 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.125 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.125 | 1 |
Brugia malayi | SET domain containing protein | 0.011 | 0.3743 | 0.4589 |
Schistosoma mansoni | enhancer of zeste ezh | 0.011 | 0.3743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.7629 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.011 | 0.3743 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0707 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0707 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0707 | 0.5 |
Brugia malayi | beta-lactamase | 0.004 | 0.0707 | 0.0363 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0707 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0707 | 0.189 |
Brugia malayi | N-terminal motif family protein | 0.02 | 0.7629 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.02 | 0.7629 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0707 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0707 | 0.0363 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0707 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0707 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.125 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0707 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0707 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.011 | 0.3743 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.125 | 0.1119 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0707 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.125 | 0.0784 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0707 | 0.0363 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0707 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0707 | 0.0363 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.125 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0707 | 0.189 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0707 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.125 | 1 |
Loa Loa (eye worm) | SET domain-containing protein | 0.011 | 0.3743 | 0.4385 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0707 | 0.189 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.125 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0707 | 0.189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.