Detailed view for Bm1_55060

Basic information

TDR Targets ID: 235128
Brugia malayi, SET domain containing protein
Source Database / ID:  GenBank

pI: 7.703 | Length (AA): 652 | MW (Da): 74737 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 648 5hyn (A) 15 740 38.00 0 1 1.05574 1.35
391 648 5hyn (A) 447 740 43.00 0 1 0.824606 0.69
465 498 4rkg (A) 523 563 35.00 0 1 0.550047 -0.8
508 640 4z4p (A) 5385 5518 34.00 0 1 0.633388 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129164)

Species Accession Gene Product
Arabidopsis thaliana AT4G02020   histone-lysine N-methyltransferase EZA1
Arabidopsis thaliana AT2G23380   histone-lysine N-methyltransferase CLF
Arabidopsis thaliana AT1G02580   histone-lysine N-methyltransferase MEDEA
Brugia malayi Bm1_55060   SET domain containing protein
Caenorhabditis elegans CELE_R06A4.7   Protein MES-2
Dictyostelium discoideum DDB_G0274259   hypothetical protein
Drosophila melanogaster Dmel_CG6502   Enhancer of zeste
Echinococcus granulosus EgrG_000439200   histone lysine N methyltransferase Ez
Echinococcus multilocularis EmuJ_000439200   histone lysine N methyltransferase E(z)
Homo sapiens ENSG00000108799   enhancer of zeste 1 polycomb repressive complex 2 subunit
Homo sapiens ENSG00000106462   enhancer of zeste 2 polycomb repressive complex 2 subunit
Loa Loa (eye worm) LOAG_00180   SET domain-containing protein
Mus musculus ENSMUSG00000006920   enhancer of zeste homolog 1 (Drosophila)
Mus musculus ENSMUSG00000029687   enhancer of zeste homolog 2 (Drosophila)
Oryza sativa 4332612   Os03g0307800
Oryza sativa 4340748   Os06g0275500
Schistosoma mansoni Smp_078900   enhancer of zeste ezh
Schmidtea mediterranea mk4.000174.06   Histone-lysine N-methyltransferase E
Schmidtea mediterranea mk4.000174.07   Histone-lysine N-methyltransferase E

Essentiality

Bm1_55060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R06A4.7 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens enhancer of zeste 1 polycomb repressive complex 2 subunit Compounds References
Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.3236 0.3868 0.3868
0.0329 0.2812 0.44
0.0228 0.3076 1
0.01 0.2542 0.251
0.0293 0.8836 1
0.0199 0.3792 0.6542
0.0623 0.9202 1
0.1868 0.5196 1
0.0329 0.5683 0.5683
0.3236 0.3868 0.3868
0.0114 0.3618 0.3618
0.0226 0.9016 0.9008
0.1212 0.8003 1
0.0199 0.3792 0.6542
0.0951 0.4236 0.5245
0.2016 0.3128 0.5812
0.4627 0.4131 0.4292
0.047 0.5567 0.8706
0.0199 0.3792 0.6542
0.3236 0.3868 0.3868
0.0575 0.6993 0.6993
0.0298 0.2805 0.4139
0.164 0.2811 0.5041
0.0199 0.3792 0.6542
0.108005 0.861711 1
0.0329 0.5683 0.5683
0.0199 0.3792 0.6542
0.0199 0.3792 0.6542
0.1868 0.5196 1
0.0228 0.3076 1
0.0951 0.4236 0.5245
0.0228 0.3076 1
0.055 0.4701 0.4701
0.0228 0.3076 0.2873
0.0219 0.2648 0.2797
0.0659 0.3617 0.4342
0.0094 0.4564 0.6359
0.0283 0.4645 0.718
0.0629 0.3144 1
0.3236 0.3868 0.3868
0.0309 0.2815 0.4344
0.1384 0.8258 1
0.0396 0.3507 0.5
0.0194 0.277 0.9638
0.0187 0.2609 1
0.0729 0.8298 1
0.0323 0.4515 0.6751
0.1063 0.3473 0.3465
0.011 0.3743 0.4589
0.0411 0.2665 0.3779
0.0615 0.4105 1
0.0523 0.3918 1
0.8665 0.533 1
0.0382 0.7103 0
0.9058 0.8485 1
0.0283 0.4645 0.718
0.0586 0.6851 1
0.0484 0.3899 1
0.0691 0.7 1
0.0215 0.266 0.2827
0.0114 0.2624 0.9638
0.0285 0.3852 0.8562
0.0281 0.2814 0.418
0.1868 0.5196 1
0.0136 0.8934 0.9025
0.0114 0.2581 0.992
0.061 0.5419 0.5418
0.2361 0.4089 0.4089
0.0282 0.7193 1
0.3236 0.3868 0.3868
0.0726 0.3898 0.3887
0.2016 0.3128 0.5812
0.0282 0.7193 1
0.094 0.6259 0.6259
0.8462 0.3629 0.376
0.0129 0.7797 0.7877
0.0215 0.266 0.2827
0.0289 0.2506 0.2705
0.02 0.5207 0.5
0.1564 0.4917 0.4917
0.0484 0.4054 0.4042
0.0329 0.5683 0.5683
0.01 0.2542 0.251
0.8462 0.3629 0.376
0.031 0.9356 1
0.3236 0.3868 0.3868
0.0218 0.3024 1
0.0114 0.2624 0.9638
0.0691 0.7 1
0.0114 0.2624 0.9638
0.0191 0.5892 1
0.0451 0.336 0.904
0.0283 0.4645 0.718
0.0423 0.4215 1
0.0192 0.7088 0.7712
0.0283 0.4645 0.718
0.0192 0.7088 0.7712
0.0329 0.2751 0.4333
0.0529 0.3865 1
0.1868 0.5196 1
0.0284 0.2817 0.426
0.0623 0.9202 1
0.0951 0.4236 0.5245
0.0192 0.7088 0.7712
0.0092 0.285 0.6977
0.0329 0.5683 0.5683
0.1868 0.5196 1
0.4577 0.6336 1
0.021 0.3861 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_55060 (Brugia malayi), SET domain containing protein
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