Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0051 | 0.0024 | 0.0024 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0017 | 0.0044 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0051 | 0.0024 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0051 | 0.0024 | 0.5 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0051 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0024 | 0.0024 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0051 | 0.0024 | 0.5 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0051 | 0.0024 | 0.0024 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0051 | 0.0024 | 0.0024 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0804 | 0.386 | 1 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0051 | 0.0024 | 0.0024 |
Schistosoma mansoni | na/ca exchanger | 0.0051 | 0.0024 | 0.0024 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.0933 | 0.2418 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0051 | 0.0024 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0024 | 0.0024 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0051 | 0.0024 | 0.0062 |
Schistosoma mansoni | sodium/calcium exchanger | 0.201 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0355 | 0.1571 | 1 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0051 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0804 | 0.386 | 0.386 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0024 | 0.0024 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0051 | 0.0024 | 0.0062 |
Loa Loa (eye worm) | solute carrier family 8 | 0.201 | 1 | 1 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0051 | 0.0024 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0355 | 0.1571 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0017 | 0.0017 |
Echinococcus multilocularis | sodium calcium exchanger | 0.201 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0017 | 0.0044 |
Plasmodium falciparum | cation/H+ antiporter | 0.0051 | 0.0024 | 0.5 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0051 | 0.0024 | 0.0024 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.0944 | 1 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0051 | 0.0024 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.