Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1079 | 1 | 0.5 |
Schistosoma mansoni | glutaminase | 0.033 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1079 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1079 | 1 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1079 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1079 | 1 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1079 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 700 uM | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | ChEMBL. | 11012024 |
IC50 (binding) | > 700 uM | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | ChEMBL. | 11012024 |
IC50 (binding) | > 700 uM | Inhibitory activity against class C Beta-lactamase isolated from Enterobacter cloacae | ChEMBL. | 11012024 |
IC50 (binding) | > 700 uM | Inhibitory activity against class A Beta-lactamase TEM isolated from Enterobacter coli | ChEMBL. | 11012024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.