pI: 8.2654 |
Length (AA): 377 |
MW (Da): 42087 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
38 | 347 | 1z1e (A) | 3 | 349 | 18.00 | 0 | 1 | 0.88 | -0.08 |
58 | 348 | 1hnj (A) | 4 | 288 | 38.00 | 0 | 1 | 1.38 | -1.13 |
45 | 376 | 4ewp (A) | 2 | 348 | 27.00 | 0 | 1 | 1.22204 | -0.51 |
56 | 377 | 2ebd (A) | 2 | 309 | 43.00 | 0 | 1 | 1.45331 | -1.39 |
56 | 377 | 1hnj (A) | 2 | 317 | 35.00 | 0 | 1 | 1.36551 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 24 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 40 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_129509)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G62640 | 3-ketoacyl-acyl carrier protein synthase III |
Chlamydia trachomatis | CT_239 | oxoacyl-ACP synthase III |
Escherichia coli | b1091 | 3-oxoacyl-[acyl-carrier-protein] synthase III |
Mycobacterium tuberculosis | Rv0533c | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) |
Mycobacterium ulcerans | MUL_3531 | 3-oxoacyl-ACP synthase |
Mycobacterium ulcerans | MUL_0632 | 3-oxoacyl-ACP synthase |
Mycobacterium ulcerans | MUP045 | beta-ketoacyl synthase-like protein |
Neospora caninum | NCLIV_031900 | 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative |
Oryza sativa | 4337178 | Os04g0643300 |
Plasmodium berghei | PBANKA_0308200 | apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative |
Plasmodium falciparum | PF3D7_0211400 | beta-ketoacyl-ACP synthase III |
Plasmodium knowlesi | PKNH_0409900 | beta-ketoacyl-acyl carrier protein synthase III precursor, putative |
Plasmodium vivax | PVX_002960 | beta-ketoacyl-acyl carrier protein synthase III precursor, putative |
Schmidtea mediterranea | mk4.058575.00 | |
Wolbachia endosymbiont of Brugia malayi | Wbm0614 | 3-oxoacyl-ACP synthase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu541 | Mycobacterium tuberculosis | non-essential | nmpdr |
b1091 | Escherichia coli | essential | goodall |
PBANKA_0308200 | Plasmodium berghei | Slow | plasmo |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Enterococcus faecalis (strain ATCC 700802 / V583) | Beta-ketoacyl-ACP synthase III | Compounds | References |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Beta-ketoacyl-ACP synthase III | Compounds | References |
Pseudomonas aeruginosa | 2-heptyl-4(1H)-quinolone synthase PqsD | Compounds | References |
Escherichia coli | 3-oxoacyl-[acyl-carrier-protein] synthase III | Compounds | References |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | Compounds | References |
Staphylococcus aureus subsp. aureus Mu50 | Beta-ketoacyl-ACP synthase III | Compounds | References |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | Compounds | References |
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) | Beta-ketoacyl-ACP synthase III | Compounds | References |