Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0135 | 0.0958 |
Mycobacterium ulcerans | methyltransferase | 0.0118 | 0.0924 | 0.0708 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0233 | 0.2822 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0135 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0189 | 0.134 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0826 | 0.3823 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.011 | 0.0779 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0051 | 0.0326 | 0.2317 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0135 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0826 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.0146 | 0.1763 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0135 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.011 | 0.0222 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.011 | 0.0222 |
Schistosoma mansoni | lamin | 0.0026 | 0.011 | 0.0779 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.1698 | 0.3439 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.0627 | 0.4454 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0051 | 0.0326 | 0.2317 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0085 | 0.0635 | 0.4511 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0135 | 0.0274 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0051 | 0.0326 | 0.0661 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.0326 | 0.2317 |
Schistosoma mansoni | o-methyltransferase | 0.0118 | 0.0924 | 0.6569 |
Brugia malayi | phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Loa Loa (eye worm) | O-methyltransferase | 0.0118 | 0.0924 | 0.1872 |
Brugia malayi | Protein kinase domain containing protein | 0.0051 | 0.0326 | 0.0661 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.0826 | 0.0923 |
Echinococcus multilocularis | insulin receptor | 0.0051 | 0.0326 | 0.2317 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.5873 |
Brugia malayi | O-methyltransferase family protein | 0.0118 | 0.0924 | 0.1872 |
Brugia malayi | O-methyltransferase | 0.0118 | 0.0924 | 0.1872 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0058 | 0.07 |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.0635 | 0.4511 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.1016 | 0.8949 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0826 | 0.3823 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Echinococcus granulosus | lamin | 0.0026 | 0.011 | 0.0779 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Onchocerca volvulus | 0.0118 | 0.0924 | 0.4426 | |
Schistosoma mansoni | o-methyltransferase | 0.0118 | 0.0924 | 0.6569 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.011 | 0.0779 |
Echinococcus granulosus | geminin | 0.0172 | 0.1407 | 1 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0118 | 0.0924 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0189 | 0.2282 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0826 | 0.3823 |
Schistosoma mansoni | o-methyltransferase | 0.0118 | 0.0924 | 0.6569 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0029 | 0.0131 | 0.158 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0125 | 0.089 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0135 | 0.0958 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1407 | 1 |
Brugia malayi | small heat shock protein | 0.0567 | 0.4938 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.195 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.0627 | 0.4454 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0159 | 0.1291 | 0.9172 |
Schistosoma mansoni | lamin | 0.0026 | 0.011 | 0.0779 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0135 | 0.0958 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0034 | 0.0176 | 0.2122 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1407 | 1 |
Trypanosoma brucei | unspecified product | 0.0034 | 0.0176 | 0.2122 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.0627 | 0.4454 |
Loa Loa (eye worm) | phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Onchocerca volvulus | 0.0232 | 0.195 | 1 | |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.5873 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 0.4938 | 1 |
Brugia malayi | O-methyltransferase family protein | 0.0118 | 0.0924 | 0.1872 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0826 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.0607 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0085 | 0.0635 | 0.4511 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0118 | 0.0924 | 0.1033 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0135 | 0.0274 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0058 | 0.0065 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0085 | 0.0635 | 0.4511 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0159 | 0.1291 | 0.9172 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0189 | 0.134 |
Schistosoma mansoni | o-methyltransferase | 0.0118 | 0.0924 | 0.6569 |
Echinococcus multilocularis | musashi | 0.0026 | 0.011 | 0.0779 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0189 | 0.134 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0135 | 0.0958 |
Onchocerca volvulus | 0.0118 | 0.0924 | 0.4426 | |
Schistosoma mansoni | tyrosine kinase | 0.0085 | 0.0635 | 0.4511 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0189 | 0.2282 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0159 | 0.1291 | 0.2614 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.0131 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0233 | 0.2822 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0189 | 0.134 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.0826 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 0.011 | 0.0779 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0159 | 0.1291 | 0.2614 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0105 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0146 | 0.0295 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0135 | 0.0958 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0029 | 0.0131 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.0826 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0019 | 0.0223 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Brugia malayi | O-methyltransferase family protein | 0.0118 | 0.0924 | 0.1872 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0131 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.0135 | 0.0137 | |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0058 | 0.07 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.0826 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0058 | 0.07 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0233 | 0.1657 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.0826 | 0.5873 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0233 | 0.1657 |
Brugia malayi | polk-prov protein | 0.003 | 0.0146 | 0.0295 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0189 | 0.0382 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0019 | 0.0223 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0118 | 0.0924 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0189 | 0.2282 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0189 | 0.2282 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.1698 | 0.3439 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0107 | 0.0826 | 1 |
Echinococcus granulosus | insulin receptor | 0.0051 | 0.0326 | 0.2317 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.0826 | 0.5873 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.004 | 0.0233 | 0.0564 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.011 | 0.0222 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0131 | 0.5 |
Echinococcus multilocularis | 0.0049 | 0.0312 | 0.2216 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0019 | 0.0223 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0826 | 0.3823 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0135 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0924 | 0.1872 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.0826 | 0.1674 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.0131 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.1291 | 0.9172 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.011 | 0.0779 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0826 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.004 | 0.0233 | 0.0564 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0233 | 0.2822 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.011 | 0.0222 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.0146 | 0.1763 |
Schistosoma mansoni | tyrosine kinase | 0.0051 | 0.0326 | 0.2317 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.011 | 0.0222 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.011 | 0.0779 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.