Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0034 | 0.0016 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | coup transcription factor | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0664 | 0.2852 | 0.5031 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Brugia malayi | nuclear receptor RXR | 0.0034 | 0.0016 | 0.0023 |
Echinococcus granulosus | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Cation transporter family protein | 0.0085 | 0.0248 | 0.0344 |
Brugia malayi | steroid hormone receptor | 0.0064 | 0.0152 | 0.021 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0698 | 0.3004 | 0.3004 |
Schistosoma mansoni | hypothetical protein | 0.0757 | 0.3268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0222 | 0.0391 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.039 | 0.1618 | 0.1883 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | 0.0757 | 0.3268 | 0.3268 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.065 | 0.2788 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | Matrilysin homolog | 0.1184 | 0.5189 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Brugia malayi | Matrixin family protein | 0.1291 | 0.5669 | 0.7839 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Hemopexin family protein | 0.0757 | 0.3268 | 0.4519 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0616 | 0.2633 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0534 | 0.2265 | 0.2265 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1184 | 0.5189 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0064 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | matrixin family protein | 0.1184 | 0.5189 | 0.9153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0016 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.065 | 0.2788 | 0.4918 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.0268 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | nuclear hormone receptor | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0195 | 0.0344 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0424 | 0.177 | 0.206 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0321 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0534 | 0.2265 | 0.693 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | nuclear hormone receptor | 0.0664 | 0.2852 | 0.3943 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0059 | 0.0082 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0424 | 0.177 | 0.5417 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0074 | 0.0195 | 0.0195 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.065 | 0.2788 | 0.3855 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | matrixin family protein | 0.1291 | 0.5669 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | Telomerase reverse transcriptase | 0.1638 | 0.7232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.2716 | 0.4791 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0085 | 0.0248 | 0.076 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0029 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Mycobacterium ulcerans | hydrolase | 0.065 | 0.2788 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1941 | 0.8592 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Onchocerca volvulus | 0.0064 | 0.0152 | 0.0152 | |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1941 | 0.8592 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0064 | 0.0152 | 0.0152 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | ecdysteroid receptor | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | 0.0534 | 0.2265 | 0.2265 | |
Giardia lamblia | Telomerase catalytic subunit | 0.0616 | 0.2633 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0085 | 0.0248 | 0.076 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0064 | 0.0152 | 0.0465 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.065 | 0.2788 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Permeability (ADMET) | 0 | BBB penetration classification | ChEMBL. | 10841799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.