Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0056 | 0.0824 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0056 | 0.0824 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0056 | 0.0824 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0056 | 0.0824 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0109 | 0.1689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0916 | 0.3509 |
Leishmania major | UDP-galactopyranose mutase | 0.0056 | 0.0824 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0056 | 0.0824 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1781 | 0.6825 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0824 | 0.3157 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0056 | 0.0824 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0056 | 0.0824 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0109 | 0.1689 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0056 | 0.0824 | 0.5 |
Onchocerca volvulus | CoRest homolog | 0.0165 | 0.261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.2533 | 0.9706 |
Brugia malayi | SWIRM domain containing protein | 0.0114 | 0.1781 | 0.7032 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.056 | 0.9084 | 1 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0824 | 0.3253 |
Echinococcus multilocularis | 0.0056 | 0.0824 | 0.4877 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0109 | 0.1689 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0061 | 0.0916 | 0.3615 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1689 | 0.6473 |
Schistosoma mansoni | amine oxidase | 0.0056 | 0.0824 | 0.4877 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0056 | 0.0824 | 0.4877 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1689 | 0.6473 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0056 | 0.0824 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.016 | 0.2533 | 1 |
Schistosoma mansoni | amine oxidase | 0.0056 | 0.0824 | 0.4877 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0056 | 0.0824 | 0.4877 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0056 | 0.0824 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0824 | 0.3157 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.261 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0056 | 0.0824 | 0.4877 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0056 | 0.0824 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0056 | 0.0824 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0616 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0056 | 0.0824 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.