Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0097 | 0.1462 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.4821 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0069 | 0.0143 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0175 | 0.2912 | 0.6039 |
Brugia malayi | Muscleblind-like protein | 0.0175 | 0.2912 | 0.2912 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0023 | 0.0069 | 0.0143 |
Brugia malayi | Cation transporter family protein | 0.0097 | 0.1462 | 0.1462 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0073 | 0.1 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.4821 | 0.4821 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0073 | 0.1 | 0.2075 |
Echinococcus granulosus | muscleblind protein | 0.0175 | 0.2912 | 0.5982 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0073 | 0.1 | 0.196 |
Onchocerca volvulus | 0.0097 | 0.1462 | 0.3403 | |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0356 | 0.6308 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.295 | 0.295 |
Onchocerca volvulus | 0.0097 | 0.1462 | 0.3403 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3046 | 0.3046 |
Onchocerca volvulus | 0.0177 | 0.295 | 1 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.4821 | 1 |
Brugia malayi | hypothetical protein | 0.0177 | 0.295 | 0.295 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0097 | 0.1462 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0069 | 0.0143 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0356 | 0.6308 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.6308 | 0.6308 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0356 | 0.6308 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1336 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0069 | 0.0143 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0023 | 0.0069 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0553 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1462 | 0.1462 |
Echinococcus multilocularis | muscleblind protein | 0.0175 | 0.2912 | 0.6039 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0023 | 0.0069 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2912 | 0.2912 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0356 | 0.6308 | 0.6308 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0694 | 0.4748 |
Brugia malayi | hypothetical protein | 0.0276 | 0.4821 | 0.4821 |
Onchocerca volvulus | 0.0097 | 0.1462 | 0.3403 | |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0694 | 0.4748 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2912 | 0.2912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate | ChEMBL. | 20536182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.