Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0096 | 0.1371 | 1 | |
Schistosoma mansoni | single-minded | 0.0048 | 0.0472 | 0.4522 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0028 | 0.0095 | 0.0095 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0472 | 0.0472 |
Brugia malayi | ADAMTS-like protease | 0.003 | 0.012 | 0.012 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0079 | 0.1043 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0149 | 0.2378 | 0.2378 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0084 | 0.1155 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0472 | 0.4522 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0028 | 0.0084 | 0.0802 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0079 | 0.1043 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.0621 | 0.0621 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0097 | 0.1382 | 0.1382 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0183 | 0.1755 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0084 | 0.0084 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0079 | 0.1043 | 0.1043 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0235 | 0.0235 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Onchocerca volvulus | Papilin homolog | 0.003 | 0.0137 | 0.0996 |
Onchocerca volvulus | Matrilysin homolog | 0.0052 | 0.0534 | 0.3892 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0052 | 0.0534 | 0.3892 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0235 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0056 | 0.0621 | 0.0621 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0235 | 0.1415 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0183 | 0.1335 | |
Onchocerca volvulus | 0.0036 | 0.0235 | 0.1716 | |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0554 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0.1043 | 0.7607 | |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.004 | 0.0322 | 0.2227 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0028 | 0.0095 | 0.5 |
Brugia malayi | hypothetical protein | 0.0162 | 0.2614 | 0.2614 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.004 | 0.0322 | 0.2227 |
Brugia malayi | Hemopexin family protein | 0.0033 | 0.0183 | 0.0183 |
Brugia malayi | angiogenesis inhibito | 0.003 | 0.012 | 0.012 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.004 | 0.0322 | 0.3089 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0079 | 0.1043 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0137 | 0.0137 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0079 | 0.1043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1397 | 0.1397 |
Loa Loa (eye worm) | matrixin family protein | 0.0052 | 0.0534 | 0.0534 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0235 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0084 | 0.1155 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0149 | 0.2378 | 0.2378 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.2614 | 0.2614 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0028 | 0.0095 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0103 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.