Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding energy (binding) | = -8.28 kCal M-1 | Free energy of binding (delta G) for inactivated state (is) of voltage-gated L-type [Ca2+] channel(VGCCs) | ChEMBL. | 10377225 |
Binding energy (binding) | = -8.277 kCal M-1 | Free energy of binding (delta G) for inactivated state (is) of voltage-gated L-type [Ca2+] channel(VGCCs) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.86 kCal M-1 | Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs)) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.86 kCal M-1 | Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs)) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.783 kCal M-1 | Free energy of binding (delta G) for inactivated state (is) of voltage-gated L-type [Ca2+] channel(VGCCs) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.783 kCal M-1 | Free energy of binding (delta G) for inactivated state (is) of voltage-gated L-type [Ca2+] channel(VGCCs) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.422 kCal M-1 | Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs)) | ChEMBL. | 10377225 |
Binding energy (binding) | = -7.422 kCal M-1 | Evaluated for the free energies of binding (delta G) (in the resting state (rs) of voltage-gated L-type [Ca2+] channel (VGCCs)) | ChEMBL. | 10377225 |
Delta Gsolv (ADMET) | = -11.269 kCal mol-1 | Solvation energy | ChEMBL. | 10377225 |
Delta Gsolv (ADMET) | = -10.096 kCal mol-1 | Solvation energy | ChEMBL. | 10377225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.