Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0437 | 0.023 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 0.9618 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.127 | 0.1072 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.6195 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.009 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1681 | 0.2714 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.6195 | 0.6108 |
Brugia malayi | Heterochromatin protein 1 | 0.0066 | 0.6195 | 0.6108 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.6195 | 0.6356 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0038 | 0.1905 | 0.1721 |
Onchocerca volvulus | 0.0087 | 0.9618 | 1 | |
Onchocerca volvulus | 0.0029 | 0.0437 | 0.023 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2268 | 0.2178 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0033 | 0.1126 | 0.0925 |
Echinococcus granulosus | jumonji domain containing protein | 0.0038 | 0.1905 | 0.1721 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.9618 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.2118 | 0.3419 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.2118 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1681 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2268 | 0.2178 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.6195 | 0.6108 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.4798 | 0.487 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.7107 | 0.7327 |
Echinococcus granulosus | ectonucleotide | 0.0034 | 0.127 | 0.1072 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.6195 | 0.6108 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.127 | 0.1116 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2268 | 0.2178 |
Echinococcus multilocularis | ectonucleotide | 0.0034 | 0.127 | 0.1072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.1681 | 0.2714 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0087 | 0.9618 | 0.961 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.6195 | 0.6356 |
Plasmodium vivax | hypothetical protein, conserved | 0.0027 | 0.0222 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0033 | 0.1126 | 0.0925 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0033 | 0.1126 | 0.0962 |
Giardia lamblia | PHD finger protein 15 | 0.0027 | 0.0222 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0027 | 0.0222 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.1681 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3292 | 0.3268 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2268 | 0.2178 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0066 | 0.6195 | 0.6356 |
Brugia malayi | chromobox protein homolog 3 | 0.0037 | 0.1681 | 0.1493 |
Plasmodium falciparum | phd finger protein, putative | 0.0027 | 0.0222 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2268 | 0.2178 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.009 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0033 | 0.1126 | 0.0962 |
Onchocerca volvulus | 0.004 | 0.2268 | 0.2178 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Onchocerca volvulus | 0.004 | 0.2268 | 0.2178 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0027 | 0.0222 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.127 | 0.1072 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2268 | 0.2093 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.004 | 0.2268 | 0.2093 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0033 | 0.1126 | 0.0962 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.2118 | 0.2018 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.6195 | 0.6108 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2268 | 0.2178 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.6195 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2268 | 0.2178 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0033 | 0.1126 | 0.0925 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 40 % | Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as residual enzyme activity by lysophosphatidulcholine release assay | ChEMBL. | 20536182 |
IC50 (binding) | = 1.63 uM | Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release | ChEMBL. | 20536182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.