Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0534 | 0.2265 | 0.693 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | nuclear hormone receptor | 0.0664 | 0.2852 | 0.3943 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0534 | 0.2265 | 0.3995 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0059 | 0.0082 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0424 | 0.177 | 0.5417 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.065 | 0.2788 | 0.3855 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0074 | 0.0195 | 0.0195 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Brugia malayi | nuclear hormone receptor | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.0268 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.021 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0424 | 0.177 | 0.206 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0195 | 0.0344 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0321 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | ecdysteroid receptor | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0064 | 0.0152 | 0.0152 |
Onchocerca volvulus | 0.0534 | 0.2265 | 0.2265 | |
Giardia lamblia | Telomerase catalytic subunit | 0.0616 | 0.2633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0085 | 0.0248 | 0.076 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.065 | 0.2788 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Loa Loa (eye worm) | matrixin family protein | 0.1291 | 0.5669 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1638 | 0.7232 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.2716 | 0.4791 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0029 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0085 | 0.0248 | 0.076 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Mycobacterium ulcerans | hydrolase | 0.065 | 0.2788 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1941 | 0.8592 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.021 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1941 | 0.8592 | 1 |
Onchocerca volvulus | 0.0064 | 0.0152 | 0.0152 | |
Schistosoma mansoni | hypothetical protein | 0.0757 | 0.3268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.039 | 0.1618 | 0.1883 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0222 | 0.0391 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | 0.0757 | 0.3268 | 0.3268 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.065 | 0.2788 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | coup transcription factor | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0034 | 0.0016 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | nuclear receptor RXR | 0.0034 | 0.0016 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0664 | 0.2852 | 0.5031 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Cation transporter family protein | 0.0085 | 0.0248 | 0.0344 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0698 | 0.3004 | 0.3004 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Loa Loa (eye worm) | matrixin family protein | 0.1184 | 0.5189 | 0.9153 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0064 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.065 | 0.2788 | 0.4918 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0016 | 0.005 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Matrixin family protein | 0.1291 | 0.5669 | 0.7839 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Onchocerca volvulus | Matrilysin homolog | 0.1184 | 0.5189 | 0.5189 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Hemopexin family protein | 0.0757 | 0.3268 | 0.4519 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Onchocerca volvulus | Matrilysin homolog | 0.0534 | 0.2265 | 0.2265 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0616 | 0.2633 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1184 | 0.5189 | 0.5189 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Permeability (ADMET) | 0 | BBB penetration classification | ChEMBL. | 10841799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.