Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.1638 | 0.7232 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0064 | 0.0152 | 0.0465 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.065 | 0.2788 | 0.5 |
Onchocerca volvulus | 0.0757 | 0.3268 | 0.3268 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Brugia malayi | Cation transporter family protein | 0.0085 | 0.0248 | 0.0344 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.0059 | 0.0082 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.065 | 0.2788 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0424 | 0.177 | 0.5417 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 0.2716 | 0.4791 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | Matrilysin homolog | 0.1184 | 0.5189 | 0.5189 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Mycobacterium ulcerans | hydrolase | 0.065 | 0.2788 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1941 | 0.8592 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | matrixin family protein | 0.1184 | 0.5189 | 0.9153 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0616 | 0.2633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0222 | 0.0391 |
Brugia malayi | steroid hormone receptor | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0664 | 0.2852 | 0.5031 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | nuclear hormone receptor | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0074 | 0.0195 | 0.0195 |
Onchocerca volvulus | Matrilysin homolog | 0.0534 | 0.2265 | 0.2265 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | matrixin family protein | 0.1291 | 0.5669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | coup transcription factor | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0029 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0085 | 0.0248 | 0.076 |
Loa Loa (eye worm) | hypothetical protein | 0.065 | 0.2788 | 0.4918 |
Onchocerca volvulus | 0.0085 | 0.0248 | 0.0248 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0195 | 0.0344 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Onchocerca volvulus | 0.0534 | 0.2265 | 0.2265 | |
Brugia malayi | Matrixin family protein | 0.1291 | 0.5669 | 0.7839 |
Brugia malayi | ecdysteroid receptor | 0.0064 | 0.0152 | 0.021 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0321 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.065 | 0.2788 | 0.3855 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Hemopexin family protein | 0.0757 | 0.3268 | 0.4519 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0016 | 0.005 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.0268 |
Schistosoma mansoni | hypothetical protein | 0.0757 | 0.3268 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0064 | 0.0152 | 0.0177 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0085 | 0.0248 | 0.076 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0016 | 0.0029 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0064 | 0.0152 | 0.0268 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0616 | 0.2633 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | nuclear receptor RXR | 0.0034 | 0.0016 | 0.0023 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0534 | 0.2265 | 0.3995 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0064 | 0.0152 | 0.0465 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0424 | 0.177 | 0.206 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0064 | 0.0152 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0034 | 0.0016 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0064 | 0.0152 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | 0.0064 | 0.0152 | 0.0152 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0064 | 0.0152 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Brugia malayi | nuclear hormone receptor | 0.0664 | 0.2852 | 0.3943 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0064 | 0.0152 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0152 | 0.0268 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0064 | 0.0152 | 0.0152 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0064 | 0.0152 | 0.0177 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.039 | 0.1618 | 0.1883 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0064 | 0.0152 | 0.0177 |
Giardia lamblia | Telomerase catalytic subunit | 0.0616 | 0.2633 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0064 | 0.0152 | 0.0177 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0698 | 0.3004 | 0.3004 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1941 | 0.8592 | 1 |
Brugia malayi | Matrixin family protein | 0.0534 | 0.2265 | 0.3132 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 0.0152 | 0.0465 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 0.0152 | 0.021 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0064 | 0.0152 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.2265 | 0.3995 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0016 | 0.0023 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0016 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0248 | 0.0438 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 0.0152 | 0.0177 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0034 | 0.0016 | 0.0019 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0534 | 0.2265 | 0.693 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0064 | 0.0152 | 0.021 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0105 | 0.0122 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0064 | 0.0152 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0064 | 0.0152 | 0.021 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1184 | 0.5189 | 0.5189 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0616 | 0.2633 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Permeability (ADMET) | 0 | BBB penetration classification | ChEMBL. | 10841799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.