Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0191 | 0.8769 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0052 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0191 | 0.8769 | 0.8769 |
Schistosoma mansoni | N-myristoyltransferase | 0.0191 | 0.8769 | 0.8757 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0151 | 0.6254 | 0.7102 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0108 | 0.3569 | 0.351 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0191 | 0.8769 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0211 | 1 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0211 | 1 | 1 |
Giardia lamblia | CDC72 | 0.0191 | 0.8769 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0211 | 1 | 1 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0151 | 0.6254 | 0.6254 |
Schistosoma mansoni | choline o-acyltransferase | 0.0211 | 1 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0151 | 0.6254 | 0.7102 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.016 | 0.6813 | 0.6784 |
Brugia malayi | TAZ zinc finger family protein | 0.0108 | 0.3569 | 0.351 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.016 | 0.6813 | 0.7746 |
Trypanosoma brucei | N-myristoyltransferase | 0.0191 | 0.8769 | 1 |
Loa Loa (eye worm) | CBP-B | 0.0075 | 0.1514 | 0.1514 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0151 | 0.6254 | 0.6219 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0151 | 0.6254 | 0.6748 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.016 | 0.6813 | 0.6784 |
Echinococcus multilocularis | CREB binding protein | 0.0074 | 0.1455 | 0.1377 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0151 | 0.6254 | 0.7102 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0211 | 1 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0067 | 0.0991 | 0.0908 |
Brugia malayi | Poly | 0.0151 | 0.6254 | 0.6219 |
Leishmania major | N-myristoyl transferase, putative | 0.0191 | 0.8769 | 1 |
Onchocerca volvulus | 0.0052 | 0.0091 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.016 | 0.6813 | 0.7746 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0191 | 0.8769 | 0.8757 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0191 | 0.8769 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.016 | 0.6813 | 0.7746 |
Echinococcus granulosus | CREB binding protein | 0.0108 | 0.3569 | 0.351 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0191 | 0.8769 | 0.5 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0108 | 0.3569 | 0.351 |
Brugia malayi | N-myristoyltransferase 2 | 0.0191 | 0.8769 | 0.8757 |
Onchocerca volvulus | 0.0052 | 0.0091 | 0.5 | |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0151 | 0.6254 | 0.6219 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0191 | 0.8769 | 1 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0151 | 0.6254 | 0.6219 |
Entamoeba histolytica | hypothetical protein | 0.0151 | 0.6254 | 0.6748 |
Onchocerca volvulus | 0.0052 | 0.0091 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6813 | 0.6813 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0191 | 0.8769 | 0.8757 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0191 | 0.8769 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0151 | 0.6254 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0052 | 0.0091 | 0.0091 |
Onchocerca volvulus | 0.0052 | 0.0091 | 0.5 | |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0191 | 0.8769 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.016 | 0.6813 | 0.6784 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.