Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0431 | 0.5867 | 0.5231 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0131 | 0.1499 | 0.2554 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.012 | 0.1334 | 0.2273 |
Brugia malayi | Serotonin receptor | 0.0461 | 0.6305 | 0.5737 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0131 | 0.1499 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0715 | 1 | 1 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0131 | 0.1499 | 0.0565 |
Brugia malayi | Carm1-pending protein | 0.0131 | 0.1499 | 0.019 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0715 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1544 | 0.0243 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.012 | 0.1334 | 0.1158 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0134 | 0.1544 | 0.0664 |
Echinococcus multilocularis | serotonin receptor | 0.0134 | 0.1544 | 0.2632 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0431 | 0.5867 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.012 | 0.1334 | 0.021 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0431 | 0.5867 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0715 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0715 | 1 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.012 | 0.1334 | 0.1158 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0431 | 0.5867 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.012 | 0.1334 | 0.2273 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.012 | 0.1334 | 0.1158 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0049 | 0.0296 | 0.0747 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0134 | 0.1544 | 0.2632 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0431 | 0.5867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.491 | 0.4127 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0131 | 0.1499 | 1 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0131 | 0.1499 | 0.2554 |
Echinococcus multilocularis | serotonin receptor | 0.0134 | 0.1544 | 0.2632 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1544 | 0.0243 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.012 | 0.1334 | 0.2273 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0431 | 0.5867 | 0.5231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.