Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma mansoni | amine GPCR | Muscarinic acetylcholine receptor M1 | 460 aa | 463 aa | 27.0 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Muscarinic acetylcholine receptor M1 | 460 aa | 462 aa | 23.4 % |
Loa Loa (eye worm) | hypothetical protein | Muscarinic acetylcholine receptor M1 | 460 aa | 425 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0057 | 0.3889 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0057 | 0.3889 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0057 | 0.3889 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0057 | 0.3889 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0057 | 0.3889 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0057 | 0.3889 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0057 | 0.3889 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0057 | 0.3889 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0057 | 0.3889 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0057 | 0.3889 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0057 | 0.3889 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | steroid hormone receptor | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0057 | 0.3889 | 1 |
Onchocerca volvulus | 0.0057 | 0.3889 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0057 | 0.3889 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0057 | 0.3889 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0057 | 0.3889 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0057 | 0.3889 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0.3889 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3889 | 0.3889 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0057 | 0.3889 | 0.3889 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0057 | 0.3889 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0099 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0057 | 0.3889 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0057 | 0.3889 | 0.3889 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0057 | 0.3889 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0057 | 0.3889 | 0.3889 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0057 | 0.3889 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0057 | 0.3889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | In vitro binding affinity towards Muscarinic acetylcholine receptor M1 by the displacement of [3H]-pirenzepine in rat cerebral cortical membranes | ChEMBL. | No reference |
IC50 (binding) | = 7 nM | In vitro binding affinity towards Muscarinic acetylcholine receptor M1 by the displacement of [3H]-pirenzepine in rat cerebral cortical membranes | ChEMBL. | No reference |
IC50 (binding) | = 14 nM | In vitro binding affinity towards Muscarinic acetylcholine receptor M1 by the displacement of [3H]-oxotremorine-M in rat brain membranes | ChEMBL. | No reference |
IC50 (binding) | = 14 nM | In vitro binding affinity towards Muscarinic acetylcholine receptor M1 by the displacement of [3H]-oxotremorine-M in rat brain membranes | ChEMBL. | No reference |
Stimulation (functional) | = 12 % | Percent stimulation of phospholipid hydrolysis in BHK cells transfected with human Muscarinic acetylcholine receptor M1 compared to maximal stimulation of carbachol at a dose of 100 uM | ChEMBL. | No reference |
Stimulation (functional) | = 12 % | Percent stimulation of phospholipid hydrolysis in BHK cells transfected with human Muscarinic acetylcholine receptor M1 compared to maximal stimulation of carbachol at a dose of 100 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.