Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0808 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0808 | 0.1003 |
Echinococcus granulosus | peptidase Clp S14 family | 0.006 | 0.2406 | 0.2107 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.416 | 0.5163 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0447 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.416 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0378 | 0.0469 |
Schistosoma mansoni | thyroid hormone receptor | 0.0169 | 0.85 | 0.8441 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0378 | 0.0469 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.3931 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0808 | 0.0447 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.8057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Onchocerca volvulus | 0.0031 | 0.0808 | 0.056 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0378 | 0.0469 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0091 | 0.416 | 0.3931 |
Brugia malayi | Probable ClpP-like protease | 0.0091 | 0.416 | 0.5163 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0378 | 0.0469 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.006 | 0.2406 | 0.2107 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0378 | 0.0469 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0808 | 0.0447 |
Onchocerca volvulus | 0.0161 | 0.8057 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0776 | 0.0963 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0808 | 0.0447 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.0808 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.719 | 0.7079 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.3931 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0808 | 0.0447 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Onchocerca volvulus | 0.0031 | 0.0808 | 0.056 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0378 | 0.0469 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | hypothetical protein | 0.0161 | 0.8057 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0091 | 0.416 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0378 | 0.0469 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0145 | 0.719 | 0.7079 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0378 | 0.0469 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.006 | 0.2406 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0378 | 0.0469 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.006 | 0.2406 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0091 | 0.416 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0808 | 0.0447 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0169 | 0.85 | 0.8441 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0091 | 0.416 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0808 | 0.0447 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0808 | 0.1003 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0378 | 0.0469 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0808 | 0.1003 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0808 | 0.0447 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0145 | 0.719 | 0.7079 |
Echinococcus multilocularis | geminin | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0378 | 0.0469 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0091 | 0.416 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.006 | 0.2406 | 0.4744 |
Schistosoma mansoni | thyroid hormone receptor | 0.0169 | 0.85 | 0.8441 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0808 | 0.1003 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0378 | 0.0469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.