Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1119 | 0.116 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.1493 | 0.1493 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.1493 | 0.1563 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0085 | 0.0718 | 0.2143 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.1493 | 0.8888 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0084 | 0.0691 | 0.1012 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0085 | 0.0718 | 0.2143 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0085 | 0.0718 | 0.0727 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0098 | 0.1119 | 0.563 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0044 | 0.0044 |
Echinococcus granulosus | glutamate receptor 2 | 0.0109 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1493 | 0.8888 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0269 | 0.6582 | 0.6582 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.1119 | 0.1119 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0131 | 0.2165 | 0.2165 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0472 | 0.0462 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.6434 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.1493 | 0.8888 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0245 | 0.5826 | 0.5826 |
Chlamydia trachomatis | glutamine binding protein | 0.0084 | 0.0691 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0085 | 0.0718 | 0.0727 |
Schistosoma mansoni | glutamate receptor kainate | 0.0085 | 0.0718 | 0.0727 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0113 | 0.1621 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0085 | 0.0718 | 0.0718 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0084 | 0.0691 | 1 |
Echinococcus granulosus | geminin | 0.0193 | 0.416 | 0.416 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.1119 | 0.1119 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0085 | 0.0718 | 0.2143 |
Schistosoma mansoni | glutamate receptor kainate | 0.0085 | 0.0718 | 0.0727 |
Onchocerca volvulus | 0.0109 | 0.1493 | 0.5 | |
Brugia malayi | Glutamate receptor 1 precursor | 0.0085 | 0.0718 | 0.2143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0113 | 0.1621 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0109 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.1493 | 0.8888 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0044 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.416 | 0.4442 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1493 | 0.8888 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.1493 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1119 | 0.116 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0113 | 0.1621 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0044 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1493 | 0.8888 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0098 | 0.1119 | 0.1119 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0044 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.416 | 0.4442 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0109 | 0.1474 | 0.1474 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0354 | 0.9309 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.1493 | 0.8888 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0085 | 0.0718 | 0.0727 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0085 | 0.0718 | 0.0727 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.1493 | 0.1493 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0109 | 0.1474 | 0.1474 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0269 | 0.6582 | 0.6582 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0109 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1621 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0098 | 0.1119 | 0.563 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0098 | 0.1119 | 0.1119 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.1493 | 0.1563 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0084 | 0.0691 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0098 | 0.1119 | 0.116 |
Schistosoma mansoni | glutamate receptor kainate | 0.0085 | 0.0718 | 0.0727 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0085 | 0.0718 | 0.0718 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0085 | 0.0718 | 0.0718 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0245 | 0.5826 | 0.5826 |
Echinococcus multilocularis | geminin | 0.0193 | 0.416 | 0.416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.