Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1773 | 0.2673 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.3922 | 0.3803 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.4163 | 0.8279 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.221 | 0.4395 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.4163 | 0.7425 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.4163 | 0.8279 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4163 | 0.4163 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2521 | 0.2374 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.4163 | 0.7425 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0122 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1536 | 0.137 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.4163 | 0.4049 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2521 | 0.2374 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.4281 | 0.4281 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4163 | 0.4163 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.5028 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2521 | 0.2374 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4163 | 0.4163 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.4163 | 0.7425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2521 | 0.2521 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.178 | 0.3541 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2521 | 0.2374 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2521 | 0.2521 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.4163 | 0.8279 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2521 | 0.2521 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1536 | 0.137 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0122 | 1 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.3922 | 0.3803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4163 | 0.4163 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.4163 | 0.4049 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.5458 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2521 | 0.5013 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0122 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4163 | 0.4163 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2018 | 0.4014 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2521 | 0.4159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.