Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0257 | 0.1484 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0007 | 0.0038 |
Brugia malayi | MH2 domain containing protein | 0.0242 | 0.1639 | 0.9475 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.003 | 0.0095 | 0.0559 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0465 | 0.269 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0007 | 0.0038 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.1639 | 0.9475 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0095 | 0.0095 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0095 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0095 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.1639 | 0.9475 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0255 | 0.173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0174 | 0.1145 | 0.6617 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0095 | 0.0547 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0095 | 0.0095 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.0362 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0465 | 0.0465 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1145 | 0.6617 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.0257 | 0.1589 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.1395 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1145 | 0.1145 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.1375 | 0.7949 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0007 | 0.0007 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0007 | 0.0007 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0465 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.173 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0007 | 0.0038 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.1375 | 0.7949 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0465 | 0.269 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Echinococcus multilocularis | tumor protein p63 | 0.0355 | 0.2453 | 0.2453 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.032 | 0.8824 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0087 | 0.0087 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0007 | 0.0007 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.0258 | 0.7098 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0255 | 0.173 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1395 | 1 | 1 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.1206 | 0.8632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0095 | 0.0547 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.1581 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0465 | 0.0465 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.0362 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0255 | 0.173 | 1 |
Onchocerca volvulus | 0.0234 | 0.1581 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0007 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0095 | 0.0095 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0595 | 0.4196 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.0362 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0007 | 0.0007 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.1206 | 0.8632 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0465 | 0.269 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0007 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.0362 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0007 | 0.0038 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0465 | 0.0465 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0007 | 0.0038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 15 % | Activation of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline | ChEMBL. | 19060912 |
Inhibition (binding) | >= 30 % | Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline | ChEMBL. | 19060912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.