Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | D-amino-acid oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | D-amino-acid oxidase | 347 aa | 378 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0195 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0298 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.0298 | 0.0298 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0298 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0298 | 0.0298 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.0298 | 1 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0298 | 1 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0195 | 1 | 1 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.0298 | 1 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.0298 | 0.0298 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0179 | 0.9091 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0016 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.0298 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.0195 | 1 | 1 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0016 | 0 | 0.5 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5000 nM | Inhibition of human DAO | ChEMBL. | 18455394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.